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TEA Domain Family Member 2 (TEAD2) (AA 267-295), (Center) antibody

Details for Product No. ABIN658203, Supplier: Log in to see
Antigen
  • TEAD2
  • ETF
  • TEAD-2
  • TEF-4
  • TEF4
  • Etdf
Epitope
AA 267-295, Center
27
15
8
3
3
2
2
2
2
1
1
Reactivity
Human, Mouse (Murine)
67
22
16
12
3
1
1
1
Host
Rabbit
43
13
11
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
4
4
4
3
3
3
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
42
38
11
9
6
5
4
4
1
Supplier
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Immunogen This TEAD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-295 AA from the Central region of human TEAD2.
Clone RB34876
Isotype Ig
Specificity This TEAD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-295 amino acids from the Central region of human TEAD2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name TEAD2 (TEAD2 Antibody Abstract)
Background Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
Synonyms: Transcriptional enhancer factor TEF-4,TEAD2,TEF4
Molecular Weight 49243 DA
Gene ID 8463
NCBI Accession NP_003589
UniProt Q15562
Research Area Transcription Factors, Translation Factors, Signaling, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment TEAD2 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-TEA Domain Family Member 2 (TEAD2) (AA 267-295), (Center) antibody (ABIN658203) TEAD2 Antibody (Center) (ABIN658203) western blot analysis in mouse NIH-3T3 cell line...
Background publications Zhang, Liu, Zha et al.: "TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition." in: The Journal of biological chemistry, Vol. 284, Issue 20, pp. 13355-62, 2009 (PubMed).

Zhao, Ye, Yu et al.: "TEAD mediates YAP-dependent gene induction and growth control." in: Genes & development, Vol. 22, Issue 14, pp. 1962-71, 2008 (PubMed).