Did you know that you can buy products from over 140 different suppliers from us?

Transcription Elongation Factor B (SIII), Polypeptide 2 (18kDa, Elongin B) (TCEB2) (AA 21-48), (Center) antibody

Details for Product No. ABIN658243
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms 0610040H15Rik, cb162, wu:fb47e08, ELOB, SIII
Epitope
AA 21-48, Center
(12), (8), (7), (7), (7), (3), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(49), (23), (17), (13), (12), (12), (1)
Host
Rabbit
(36), (17), (3)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(46), (29), (10), (9), (7), (3), (2), (1)
Pubmed 2 references available
Quantity 400 µL
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN658243
291.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This TCEB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-48 AA from the Central region of human TCEB2.
Clone RB20802
Isotype Ig
Specificity This TCEB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-48 amino acids from the Central region of human TCEB2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name TCEB2
Background This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13.
Synonyms: Transcription elongation factor B polypeptide 2,TCEB2,
Molecular Weight 13133 DA
Gene ID 6923
UniProt NP_009039.1, Q15370
Research Area Signaling, Protein Modifications, Transcription Factors, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.4 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment TCEB2 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Transcription Elongation Factor B (SIII), Polypeptide 2 (18kDa, Elongin B) (TCEB2) (AA 21-48), (Center) antibody TCEB2 Antibody (Center) (ABIN658243) western blot analysis in K562 cell line lysates (35 µg/lane). This demonstrates the TCEB2 antibody detected the TCEB2 protein (arrow).
Background publications Bullock, Debreczeni, Edwards et al.: "Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 20, pp. 7637-42, 2006 (PubMed).

Van Herreweghe, Egloff, Goiffon et al.: "Dynamic remodelling of human 7SK snRNP controls the nuclear level of active P-TEFb." in: The EMBO journal, Vol. 26, Issue 15, pp. 3570-80, 2007 (PubMed).

Validation Images
back to top