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Details for Product No. ABIN658243

Transcription Elongation Factor B (SIII), Polypeptide 2 (18kDa, Elongin B) (TCEB2) (AA 21-48), (Center) antibody

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Antigen
Synonyms ELOB, SIII, 0610040H15Rik, cb162, wu:fb47e08
Epitope
»Alternatives AA 21-48, Center
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN658243
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This TCEB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-48 AA from the Central region of human TCEB2.
Clone RB20802
Isotype Ig
Specificity This TCEB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-48 amino acids from the Central region of human TCEB2.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name TCEB2
Background This gene encodes the protein elongin B, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Pseudogenes have been identified on chromosomes 11 and 13.
Synonyms: Transcription elongation factor B polypeptide 2,TCEB2,
Molecular Weight 13133 DA
Gene ID 6923
UniProt NP_009039.1, Q15370
Research Area Signaling, Protein Modifications, Transcription Factors, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.4 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment TCEB2 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Bullock, Debreczeni, Edwards et al.: "Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 20, pp. 7637-42, 2006 (PubMed).

Van Herreweghe, Egloff, Goiffon et al.: "Dynamic remodelling of human 7SK snRNP controls the nuclear level of active P-TEFb." in: The EMBO journal, Vol. 26, Issue 15, pp. 3570-80, 2007 (PubMed).

Alternatives for antigen "Transcription Elongation Factor B (SIII), Polypeptide 2 (18kDa, Elongin B) (TCEB2)", type "Antibodies"
Hosts (25), (12), (3)
Reactivities (37), (19), (17), (13), (12), (12), (1)
Applications (29), (15), (10), (6), (3), (3), (3), (1), (1)
Conjugates (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (12), (4), (2), (2), (2), (2), (1), (1), (1), (1), (1)
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