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Details for Product No. ABIN658255

Nuclear Transcription Factor Y, beta (NFYB) (N-Term), (AA 17-46) antibody

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Antigen
Synonyms HAP3, CBF-A, CBF-B, NF-YB, nfyb, zgc:110533, AA985999, Cbf-A, CBFB, Nfya, NFYB, hap3, cbf-a, cbf-b
Epitope
»Alternatives N-Term, AA 17-46
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB), Immunofluorescence (IF)
Pubmed 3 references available
Catalog no. ABIN658255
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This NFYB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-46 AA from the N-terminal region of human NFYB.
Clone RB30270
Isotype Ig
Specificity This NFYB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of human NFYB.
Predicted Reactivity Cow (Bovine),Chicken,Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name NFYB
Background The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence, protein sequence alignments and experiments with mutants.
Synonyms: Nuclear transcription factor Y subunit beta,NFYB,HAP3
Molecular Weight 22831 DA
Gene ID 4801
UniProt P25208, NP_006157.1
Research Area Translation Factors, Transcription Factors, Signaling, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IF : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.42 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment NFYB Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Di Agostino, Strano, Emiliozzi et al.: "Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation." in: Cancer cell, Vol. 10, Issue 3, pp. 191-202, 2006 (PubMed).

Raju, Göritz, Nord et al.: "In cultured oligodendrocytes the A/B-type hnRNP CBF-A accompanies MBP mRNA bound to mRNA trafficking sequences." in: Molecular biology of the cell, Vol. 19, Issue 7, pp. 3008-19, 2008 (PubMed).

Stros, Polanská, Struncová et al.: "HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha." in: Nucleic acids research, Vol. 37, Issue 7, pp. 2070-86, 2009 (PubMed).

Alternatives for antigen "Nuclear Transcription Factor Y, beta (NFYB)", type "Antibodies"
Hosts (29), (13)
Reactivities (41), (10), (8), (2), (2), (2), (1), (1), (1)
Applications (37), (27), (12), (11), (5), (4), (3), (3), (2), (1), (1), (1), (1)
Epitopes (15), (7), (1), (1), (1), (1), (1), (1)
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