Nuclear Transcription Factor Y, beta (NFYB) (N-Term), (AA 17-46) antibody

Details for Product No. ABIN658255
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Antigen
Epitope
N-Term, AA 17-46
Reactivity
Human
Host
Rabbit
Clonality (Clone)
Polyclonal ()
Application
Western Blotting (WB), Immunofluorescence (IF)
Pubmed 3 references available
Quantity 400 μL
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Catalog No. ABIN658255
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Immunogen This NFYB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-46 AA from the N-terminal region of human NFYB.
Clone RB30270
Isotype Ig
Specificity This NFYB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of human NFYB.
Predicted Reactivity Cow (Bovine),Chicken,Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name NFYB
Background The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence, protein sequence alignments and experiments with mutants.
Synonyms: Nuclear transcription factor Y subunit beta,NFYB,HAP3
Molecular Weight 22831 DA
Gene ID 4801
NCBI Accession NP_006157
UniProt P25208
Research Area Translation Factors, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:1000, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.42 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment NFYB Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Nuclear Transcription Factor Y, beta (NFYB) (N-Term), (AA 17-46) antibody NFYB Antibody (N-term) (ABIN658255) western blot analysis in A549 cell line lysates (35 µg/lane). This demonstrates the NFYB antibody detected the NFYB protein (arrow).
Background publications Stros, Polanská, Struncová et al.: "HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha." in: Nucleic acids research, Vol. 37, Issue 7, pp. 2070-86, 2009 (PubMed).

Raju, Göritz, Nord et al.: "In cultured oligodendrocytes the A/B-type hnRNP CBF-A accompanies MBP mRNA bound to mRNA trafficking sequences." in: Molecular biology of the cell, Vol. 19, Issue 7, pp. 3008-19, 2008 (PubMed).

Di Agostino, Strano, Emiliozzi et al.: "Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation." in: Cancer cell, Vol. 10, Issue 3, pp. 191-202, 2006 (PubMed).

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