Membrane-Associated Ring Finger (C3HC4) 1, E3 Ubiquitin Protein Ligase (MARCH1) (AA 163-191), (Center) antibody

Details for Product No. ABIN658266
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Antigen
Synonyms 2900024D24Rik, BB085186, MARCH-I, RNF171, RGD1305148
Epitope
AA 163-191, Center
(9), (7), (2), (2), (1), (1)
Reactivity
Mouse (Murine)
(34), (21), (20), (17), (17), (17)
Host
Rabbit
(29), (4), (3)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(16), (15), (13), (10), (3), (1)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN658266
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Immunogen This MARCH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-191 AA from the Central region of human MARCH1.
Clone RB33494
Isotype Ig
Specificity This MARCH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-174 amino acids from the Central region of human MARCH1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name MARCH1
Background MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266], Thibodeau et al., 2008 [PubMed 18389477], De Gassart et al., 2008 [PubMed 18305173]).
Synonyms: E3 ubiquitin-protein ligase MARCH1,MARCH1,RNF171
Molecular Weight 32308 DA
Gene ID 55016
NCBI Accession NP_001159845, NP_060393
UniProt Q8TCQ1
Research Area Cell Signaling, Cell Structure, Chromatin, Signaling
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment MARCH1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Membrane-Associated Ring Finger (C3HC4) 1, E3 Ubiquitin Protein Ligase (MARCH1) (AA 163-191), (Center) antibody MARCH1 Antibody (Center) (ABIN658266) western blot analysis in mouse heart tissue lysates (35 µg/lane). This demonstrates the MARCH1 antibody detected the MARCH1 protein (arrow).
Background publications Bartee, Mansouri, Hovey Nerenberg et al.: "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins." in: Journal of virology, Vol. 78, Issue 3, pp. 1109-20, 2004 (PubMed).

De Gassart, Camosseto, Thibodeau et al.: "MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 9, pp. 3491-6, 2008 (PubMed).

Validation Images
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