SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1) (N-Term) antibody

Antigen: SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1)

Synonyms: RDT, INI1, SNF5, Snr1, BAF47, Sfh1p, hSNFS, SNF5L1

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN658274

Additional Information

Alternative name: SMARCB1

Gene ID: 6598

UniProt: NP_001007469.1, NP_003064.2, Q12824

Immunogen: This SMARCB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-81 amino acids from the N-terminal region of human SMARCB1.

Isotype: Ig

Description: Other names: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1,SMARCB1,BAF47, INI1, SNF5L1

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This SMARCB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 51-81 amino acids from the N-terminal region of human SMARCB1.

Molecular Weight: 44141 DA

Comments:

Background: The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: SMARCB1 Antibody (N-term) can be refrigerated at 2-8° C for up to 6 months. For long term storage, place the at -20° C.

Research Area: Translation Factors, Phospho-specific antibodies, Protein Modifications, Cancer, Transcription Factors, Chromatin, Signaling, Neurology, Cell Structure

Restrictions: For Research Use only

Images

SMARCB1 Antibody (N-term) (ABIN658274) western blot analysis in mouse brain tissue lysates (35ug/lane). This demonstrates the SMARCB1 antibody detected the SMARCB1 protein (arrow).

Publications

Product: Kohashi, Oda, Yamamoto et al.: "Reduced expression of SMARCB1/INI1 protein in synovial sarcoma." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 23, Issue 7, pp. 981-90, 2010 (PubMed).

Bakshi, Hassan, Pratap et al.: "The human SWI/SNF complex associates with RUNX1 to control transcription of hematopoietic target genes." in: Journal of cellular physiology, Vol. 225, Issue 2, pp. 569-76, 2010 (PubMed).