5'-3' Exoribonuclease 2 (XRN2) (N-Term) antibody

Antigen: 5'-3' Exoribonuclease 2 (XRN2)

Synonyms: zgc:55717, wu:fb38g12, wu:fj53d06, DKFZp459J063

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN658280

Additional Information

Alternative name: XRN2

Gene ID: 22803

UniProt: NP_036387.2, Q9H0D6

Immunogen: This XRN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 47-76 amino acids from the N-terminal region of human XRN2.

Isotype: Ig

Description: Other names: 5'-3' exoribonuclease 2,XRN2,

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This XRN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 47-76 amino acids from the N-terminal region of human XRN2.

Molecular Weight: 108582 DA

Comments:

Background: This gene shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The yeast gene is involved in homologous recombination and RNA metabolism, such as RNA synthesis and RNA trafficking. Complementation studies show that Dhm1 has a similar function in mouse as dhp1. The function of the human gene has not yet been determined. Transcript variants encoding different isoforms have been noted for this gene, however, their full-length nature is not known.

Application Details

Application Notes: The suggested dilution is: ELISA ~~ 1:1,000 Western blotting~~ 1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: XRN2 Antibody (N-term) can be refrigerated at 2-8° C for up to 6 months. For long term storage, place the at -20° C.

Research Area: Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Metabolism, Cell Structure

Restrictions: For Research Use only

Images

XRN2 Antibody (N-term) (ABIN658280) western blot analysis in T47D cell line lysates (35ug/lane). This demonstrates the XRN2 antibody detected the XRN2 protein (arrow).

Publications

Product: Lu, Liu, James et al.: "Genetic variants cis-regulating Xrn2 expression contribute to the risk of spontaneous lung tumor." in: Oncogene, Vol. 29, Issue 7, pp. 1041-9, 2010 (PubMed).