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ARIH2 antibody (protein ariadne-2 homolog) (AA 445-474)

Details for Product anti-ARIH2 Antibody No. ABIN658296, Supplier: Log in to see
Antigen
  • AI843547
  • ARI2
  • TRIAD1
  • UIP48
Epitope
AA 445-474, C-Term
28
15
6
4
3
2
2
2
2
2
1
Reactivity
Human
71
21
14
5
4
3
2
2
1
1
1
1
Host
Rabbit
44
14
13
Clonality (Clone)
Polyclonal ()
Conjugate
This ARIH2 antibody is un-conjugated
3
3
3
3
3
3
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
64
40
22
13
8
4
3
3
1
Supplier
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Immunogen This ARIH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 445-474 AA from the C-terminal region of human ARIH2.
Clone RB34249
Isotype Ig
Specificity This ARIH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 444-474 amino acids from the C-terminal region of human ARIH2.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ARIH2
Background E3 ubiquitin-protein ligase mediating 'Lys-48'-and 'Lys-63'-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis.
Synonyms: E3 ubiquitin-protein ligase ARIH2,ARIH2,ARI2, TRIAD1
Molecular Weight 57819 DA
Gene ID 10425
NCBI Accession NP_006312
UniProt O95376
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment ARIH2 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-ARIH2 antibody (protein ariadne-2 homolog) (AA 445-474) (ABIN658296) Western blot analysis of ARIH2 (arrow) using rabbit polyclonal ARIH2 Antibody (C-term...
Background publications Marteijn, van der Meer, Smit, Noordermeer, Wissink, Jansen, Swarts, Hibbert, de Witte, Sixma, Jansen, van der Reijden: "The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains." in: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, Vol. 23, Issue 8, pp. 1480-9, 2009

Marteijn, van der Meer, van Emst, van Reijmersdal, Wissink, de Witte, Jansen, Van der Reijden: "Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1." in: Blood, Vol. 110, Issue 9, pp. 3128-35, 2007

Matsuoka, Ballif, Smogorzewska, McDonald, Hurov, Luo, Bakalarski, Zhao, Solimini, Lerenthal, Shiloh, Gygi, Elledge: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007

Marteijn, van Emst, Erpelinck-Verschueren, Nikoloski, Menke, de Witte, Löwenberg, Jansen, van der Reijden: "The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells." in: Blood, Vol. 106, Issue 13, pp. 4114-23, 2005

Stelzl, Worm, Lalowski, Haenig, Brembeck, Goehler, Stroedicke, Zenkner, Schoenherr, Koeppen, Timm, Mintzlaff, Abraham, Bock, Kietzmann, Goedde, Toksöz, Droege, Krobitsch, Korn, Birchmeier, Lehrach et al.: "A human protein-protein interaction network: a resource for annotating the proteome. ..." in: Cell, Vol. 122, Issue 6, pp. 957-68, 2005