protein ariadne-2 homolog (ARIH2) (C-Term), (AA 445-474) antibody

Details for Product No. ABIN658296
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Antigen
Epitope
C-Term, AA 445-474
(9), (7), (6), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(46), (20), (19), (14), (14), (13), (3), (2)
Host
Rabbit
(36), (6), (4)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(31), (16), (11), (10), (5), (3), (3), (2), (2), (2)
Pubmed 5 references available
Quantity 400 µL
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Catalog No. ABIN658296
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Immunogen This ARIH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 445-474 AA from the C-terminal region of human ARIH2.
Clone RB34249
Isotype Ig
Specificity This ARIH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 444-474 amino acids from the C-terminal region of human ARIH2.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ARIH2
Background E3 ubiquitin-protein ligase mediating 'Lys-48'-and 'Lys-63'-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis.
Synonyms: E3 ubiquitin-protein ligase ARIH2,ARIH2,ARI2, TRIAD1
Molecular Weight 57819 DA
Gene ID 10425
NCBI Accession NP_006312
UniProt O95376
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Protein Modifications, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment ARIH2 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-protein ariadne-2 homolog (ARIH2) (C-Term), (AA 445-474) antibody Western blot analysis of ARIH2 (arrow) using rabbit polyclonal ARIH2 Antibody (C-term) (ABIN658296). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ARIH2 gene.
Background publications Marteijn, van Emst, Erpelinck-Verschueren et al.: "The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells." in: Blood, Vol. 106, Issue 13, pp. 4114-23, 2005 (PubMed).

Stelzl, Worm, Lalowski et al.: "A human protein-protein interaction network: a resource for annotating the proteome...." in: Cell, Vol. 122, Issue 6, pp. 957-68, 2005 (PubMed).

Matsuoka, Ballif, Smogorzewska et al.: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).

Marteijn, van der Meer, van Emst et al.: "Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1." in: Blood, Vol. 110, Issue 9, pp. 3128-35, 2007 (PubMed).

Marteijn, van der Meer, Smit et al.: "The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains." in: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K, Vol. 23, Issue 8, pp. 1480-9, 2009 (PubMed).

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