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serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) (AA 19-47), (N-Term) antibody

Details for Product No. ABIN658344, Supplier: Log in to see
Antigen
  • AI324848
  • AI385541
  • C81125
  • CSHMT
  • F20D10.50
  • F20D10_50
  • LRRGT00032
  • MEL-32
  • MGC53442
  • mShmt
  • mshmt
  • mshmt1
  • mshmt2
  • SERINE HYDROXYMETHYLTRANSFERASE 1
  • SERINE TRANSHYDROXYMETHYLASE
  • SERINE TRANSHYDROXYMETHYLTRANSFERASE
  • serine transhydroxymethyltransferase 1
  • SHMT
  • Shmt
  • SHMT1
  • shmt1
  • Shmt1
  • SHMT2
  • STM
  • zgc:66171
  • zgc:77524
Epitope
AA 19-47, N-Term
19
15
12
3
3
2
2
2
1
1
Reactivity
Human
59
5
4
1
1
1
Host
Rabbit
42
18
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
3
3
3
3
3
3
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
56
32
29
8
2
1
1
1
Supplier
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Immunogen This SHMT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-47 AA from the N-terminal region of human SHMT1.
Clone RB34397
Isotype Ig
Specificity This SHMT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-47 amino acids from the N-terminal region of human SHMT1.
Predicted Reactivity Cow (Bovine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name SHMT1 (SHMT1 Antibody Abstract)
Background This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined.
Synonyms: Serine hydroxymethyltransferase, cytosolic,SHMT1,
Molecular Weight 53083 DA
Gene ID 6470
NCBI Accession NP_004160, NP_683718
UniProt P34896
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Metabolism, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment SHMT1 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) (AA 19-47), (N-Term) antibody (ABIN658344) SHMT1 Antibody (N-term) (ABIN658344) western blot analysis in 293 cell line lysates (...
Product cited in: Sun, Song, Wan, Wu, Li, Wang, Wang, Liu, Zhong, He, Shen, Pan, Li, Wang, Gao, Tang, Zhang: "cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions." in: Cell research, Vol. 25, Issue 4, pp. 429-44, 2015 (PubMed).

Background publications Summers, Mitchell, Stanislawska-Sachadyn, Baido, Blair, Von Feldt, Whitehead: "Genetic and lifestyle variables associated with homocysteine concentrations and the distribution of folate derivatives in healthy premenopausal women." in: Birth defects research. Part A, Clinical and molecular teratology, Vol. 88, Issue 8, pp. 679-88, 2010 (PubMed).

Levine, Figueiredo, Lee, Conti, Kennedy, Duggan, Poynter, Campbell, Newcomb, Martinez, Hopper, Le Marchand, Baron, Limburg, Ulrich, Haile: "A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 7, pp. 1812-21, 2010 (PubMed).

Jugessur, Shi, Gjessing, Lie, Wilcox, Weinberg, Christensen, Boyles, Daack-Hirsch, Nguyen, Christiansen, Lidral, Murray: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).