serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) (N-Term), (AA 19-47) antibody

Details for Product No. ABIN658344
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Antigen
Synonyms
Shmt, mshmt, C81125, mshmt1, mshmt2, AI324848, AI385541, mShmt, LRRGT00032, MEL-32, CSHMT, SHMT, SHMT2, F20D10.50, F20D10_50, SERINE HYDROXYMETHYLTRANSFERASE 1, SERINE TRANSHYDROXYMETHYLASE, SERINE TR ... show more
Shmt, mshmt, C81125, mshmt1, mshmt2, AI324848, AI385541, mShmt, LRRGT00032, MEL-32, CSHMT, SHMT, SHMT2, F20D10.50, F20D10_50, SERINE HYDROXYMETHYLTRANSFERASE 1, SERINE TRANSHYDROXYMETHYLASE, SERINE TRANSHYDROXYMETHYLTRANSFERASE, SHMT1, STM, serine transhydroxymethyltransferase 1, shmt1, MGC53442, zgc:66171, zgc:77524, Shmt1 show less
Epitope
N-Term, AA 19-47
(3), (3), (2), (2), (2), (1), (1)
Reactivity
Human
(19), (3), (3), (1), (1), (1)
Host
Rabbit
(13), (7)
Clonality (Clone)
Polyclonal ()
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(20), (8), (5), (2), (1)
Pubmed 3 references available
Catalog no. ABIN658344
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This SHMT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-47 AA from the N-terminal region of human SHMT1.
Clone RB34397
Isotype Ig
Specificity This SHMT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-47 amino acids from the N-terminal region of human SHMT1.
Predicted Reactivity Cow (Bovine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name SHMT1
Background This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined.
Synonyms: Serine hydroxymethyltransferase, cytosolic,SHMT1,
Molecular Weight 53083 DA
Gene ID 6470
UniProt NP_004160.3, NP_683718.1, P34896
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Metabolism, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment SHMT1 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) (N-Term), (AA 19-47) antibody SHMT1 Antibody (N-term) (ABIN658344) western blot analysis in 293 cell line lysates (35 µg/lane). This demonstrates the SHMT1 antibody detected the SHMT1 protein (arrow).
Background publications Summers, Mitchell, Stanislawska-Sachadyn et al.: "Genetic and lifestyle variables associated with homocysteine concentrations and the distribution of folate derivatives in healthy premenopausal women." in: Birth defects research. Part A, Clinical and molecular teratology, Vol. 88, Issue 8, pp. 679-88, 2010 (PubMed).

Levine, Figueiredo, Lee et al.: "A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 7, pp. 1812-21, 2010 (PubMed).

Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).

Hosts (13), (7)
Reactivities (19), (3), (3), (1), (1), (1)
Applications (20), (8), (5), (2), (1)
Epitopes (3), (3), (2), (2), (2), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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