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Details for Product No. ABIN658344

serine Hydroxymethyltransferase 1 (Soluble) (SHMT1) (N-Term), (AA 19-47) antibody

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Antigen
Synonyms
Shmt, mshmt, C81125, mshmt1, mshmt2, AI324848, AI385541, mShmt, LRRGT00032, MEL-32, CSHMT, SHMT, SHMT2, F20D10.50, F20D10_50, SERINE HYDROXYMETHYLTRANSFERASE 1, SERINE TRANSHYDROXYMETHYLASE, SERINE TR ... show more
Epitope
»Alternatives N-Term, AA 19-47
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 3 references available
Catalog no. ABIN658344
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This SHMT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-47 AA from the N-terminal region of human SHMT1.
Clone RB34397
Isotype Ig
Specificity This SHMT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-47 amino acids from the N-terminal region of human SHMT1.
Predicted Reactivity Cow (Bovine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name SHMT1
Background This gene encodes the cellular form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing of this gene results in 2 transcript variants encoding 2 different isoforms. Additional transcript variants have been described, but their biological validity has not been determined.
Synonyms: Serine hydroxymethyltransferase, cytosolic,SHMT1,
Molecular Weight 53083 DA
Gene ID 6470
UniProt NP_004160.3, NP_683718.1, P34896
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Metabolism, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:10-50
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment SHMT1 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Summers, Mitchell, Stanislawska-Sachadyn et al.: "Genetic and lifestyle variables associated with homocysteine concentrations and the distribution of folate derivatives in healthy premenopausal women." in: Birth defects research. Part A, Clinical and molecular teratology, Vol. 88, Issue 8, pp. 679-88, 2010 (PubMed).

Levine, Figueiredo, Lee et al.: "A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 19, Issue 7, pp. 1812-21, 2010 (PubMed).

Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).

Alternatives for antigen "serine Hydroxymethyltransferase 1 (Soluble) (SHMT1)", type "Antibodies"
Hosts (12), (8)
Reactivities (19), (2), (2), (1), (1), (1)
Applications (20), (9), (6), (2), (2), (1)
Epitopes (4), (3), (2), (2), (2), (1), (1), (1)
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