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Details for Product No. ABIN658397

Lysine (K)-Specific Demethylase 5B (KDM5B) (N-Term), (AA 192-224) antibody

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Antigen
Synonyms
2010009J12Rik, 2210016I17Rik, AW556288, D1Ertd202e, Jarid1b, PLU-1, PUT1, Plu1, RBBP2H1A, Rb-Bp2, mKIAA4034, RGD1565602, JARID1B, CT31, PLU1, jarid1b, jarid1ba, id:ibd5050, wu:fd15c05, cb264, jarid1bb ... show more
Epitope
»Alternatives N-Term, AA 192-224
Reactivity
»Alternatives Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN658397
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This JARID1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-224 AA from the N-terminal region of human JARID1B.
Clone RB10763
Isotype Ig
Specificity This JARID1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-225 amino acids from the N-terminal region of human JARID1B.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name JARID1B
Background Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.
Synonyms: Lysine-specific demethylase 5B,KDM5B,JARID1B, PLU1, RBBP2H1
Molecular Weight 175658 DA
Gene ID 10765
UniProt NP_006609.3, Q9UGL1
Research Area Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Signaling, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.41 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment JARID1B Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Hayami, Yoshimatsu, Veerakumarasivam et al.: "Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway." in: Molecular cancer, Vol. 9, pp. 59, 2010 (PubMed).

Yao, Peng, Lin: "The flexible loop L1 of the H3K4 demethylase JARID1B ARID domain has a crucial role in DNA-binding activity." in: Biochemical and biophysical research communications, Vol. 396, Issue 2, pp. 323-8, 2010 (PubMed).

Roesch, Fukunaga-Kalabis, Schmidt et al.: "A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth." in: Cell, Vol. 141, Issue 4, pp. 583-94, 2010 (PubMed).

Krishnakumar, Kraus: "PARP-1 regulates chromatin structure and transcription through a KDM5B-dependent pathway." in: Molecular cell, Vol. 39, Issue 5, pp. 736-49, 2010 (PubMed).

Kim, Shin, Subramaniam et al.: "Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10." in: Biochemical and biophysical research communications, Vol. 401, Issue 3, pp. 412-6, 2010 (PubMed).

Alternatives for antigen "Lysine (K)-Specific Demethylase 5B (KDM5B)", type "Antibodies"
Hosts (16), (14)
Reactivities (29), (16), (14), (12), (12), (12), (12), (12)
Applications (17), (13), (10), (4), (2), (2), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (3), (2), (1), (1), (1)
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