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Deoxynucleotidyltransferase, terminal (DNTT) (AA 42-70), (N-Term) antibody

Details for Product No. ABIN658399, Supplier: Login to see
Antigen
  • TdT
  • TDT
  • BB160593
  • Tdt
  • dntt-A
  • dntt
Alternatives
anti-Human Deoxynucleotidyltransferase, terminal antibody for Immunohistochemistry
Epitope
AA 42-70, N-Term
39
32
16
15
9
3
3
3
3
2
2
2
2
1
1
1
1
1
Reactivity
Human
135
30
23
7
5
3
2
1
Host
Rabbit
111
30
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
10
7
5
4
4
4
1
1
1
Application
Western Blotting (WB)
95
50
23
14
11
10
6
5
5
4
2
2
2
1
1
Supplier
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Immunogen This TDT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-70 AA from the N-terminal region of human TDT.
Clone RB18826
Isotype Ig
Specificity This TDT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-70 amino acids from the N-terminal region of human TDT.
Predicted Reactivity Cow (Bovine),Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name TDT (DNTT Antibody Abstract)
Background This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
Synonyms: DNA nucleotidylexotransferase,DNTT,TDT
Molecular Weight 58536 DA
Gene ID 1791
NCBI Accession NP_004079, NP_001017520
UniProt P04053
Research Area Protein Modifications, Chromatin, Signaling, Cell Structure
Pathways DNA Damage Repair
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment TDT Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Deoxynucleotidyltransferase, terminal (DNTT) (AA 42-70), (N-Term) antibody (ABIN658399) TDT Antibody (N-term) (ABIN658399) western blot analysis in MDA-MB453 cell line lysat...
Background publications Liu, McGavran, Lovell et al.: "Nonpositive terminal deoxynucleotidyl transferase in pediatric precursor B-lymphoblastic leukemia." in: American journal of clinical pathology, Vol. 121, Issue 6, pp. 810-5, 2004 (PubMed).