Deoxynucleotidyltransferase, terminal (DNTT) (N-Term), (AA 42-70) antibody

Details for Product No. ABIN658399
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Antigen
Epitope
N-Term, AA 42-70
(20), (19), (15), (8), (7), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(105), (26), (23), (14), (5), (3), (1), (1)
Host
Rabbit
(89), (27)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(6), (6), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(67), (31), (23), (13), (10), (7), (6), (5), (4), (2), (2), (1), (1)
Pubmed 1 reference available
Quantity 400 μL
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Catalog No. ABIN658399
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Immunogen This TDT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-70 AA from the N-terminal region of human TDT.
Clone RB18826
Isotype Ig
Specificity This TDT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-70 amino acids from the N-terminal region of human TDT.
Predicted Reactivity Cow (Bovine),Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name TDT
Background This gene is a member of the DNA polymerase type-X family and encodes a template-independent DNA polymerase that catalyzes the addition of deoxynucleotides to the 3'-hydroxyl terminus of oligonucleotide primers. In vivo, the encoded protein is expressed in a restricted population of normal and malignant pre-B and pre-T lymphocytes during early differentiation, where it generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Alternatively spliced transcript variants encoding different isoforms of this gene have been described.
Synonyms: DNA nucleotidylexotransferase,DNTT,TDT
Molecular Weight 58536 DA
Gene ID 1791
NCBI Accession NP_004079, NP_001017520
UniProt P04053
Research Area Protein Modifications, Chromatin, Signaling, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment TDT Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Deoxynucleotidyltransferase, terminal (DNTT) (N-Term), (AA 42-70) antibody TDT Antibody (N-term) (ABIN658399) western blot analysis in MDA-MB453 cell line lysates (35 µg/lane). This demonstrates the TdT antibody detected the TdT protein (arrow).
Background publications Liu, McGavran, Lovell et al.: "Nonpositive terminal deoxynucleotidyl transferase in pediatric precursor B-lymphoblastic leukemia." in: American journal of clinical pathology, Vol. 121, Issue 6, pp. 810-5, 2004 (PubMed).

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