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Kruppel-Like Factor 1 (erythroid) (KLF1) (AA 248-276), (C-Term) antibody

Details for Product No. ABIN658420, Supplier: Login to see
Antigen
  • KLF1
  • EKLF
  • HBFQTL6
  • INLU
  • Eklf
  • Nan
Epitope
AA 248-276, C-Term
23
16
10
9
6
4
3
2
2
1
Reactivity
Human
57
20
6
6
5
3
1
Host
Rabbit
33
18
16
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
3
3
3
3
3
3
Application
Western Blotting (WB)
58
49
7
6
4
4
3
1
1
Supplier
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Immunogen This KLF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 248-276 AA from the C-terminal region of human KLF1.
Clone RB34111
Isotype Ig
Specificity This KLF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 247-276 amino acids from the C-terminal region of human KLF1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name KLF1 (KLF1 Antibody Abstract)
Background This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype.
Synonyms: Krueppel-like factor 1,KLF1,EKLF
Molecular Weight 38221 DA
Gene ID 10661
NCBI Accession NP_006554
UniProt Q13351
Research Area Ubiquitin-related antibodies, Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Cell Structure
Pathways
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment KLF1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Kruppel-Like Factor 1 (erythroid) (KLF1) (AA 248-276), (C-Term) antibody (ABIN658420) KLF1 Antibody (C-term) (ABIN658420) western blot analysis in NCI-H292 cell line lysat...
Background publications Borg, Papadopoulos, Georgitsi et al.: "Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin." in: Nature genetics, Vol. 42, Issue 9, pp. 801-5, 2010 (PubMed).

Zhou, Liu, Sun et al.: "KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching." in: Nature genetics, Vol. 42, Issue 9, pp. 742-4, 2010 (PubMed).