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Details for Product No. ABIN658420

Kruppel-Like Factor 1 (erythroid) (KLF1) (C-Term), (AA 248-276) antibody

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Antigen
Synonyms EKLF, HBFQTL6, INLU, Eklf, Nan, KLF1
Epitope
»Alternatives C-Term, AA 248-276
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB)
Pubmed 2 references available
Catalog no. ABIN658420
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This KLF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 248-276 AA from the C-terminal region of human KLF1.
Clone RB34111
Isotype Ig
Specificity This KLF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 247-276 amino acids from the C-terminal region of human KLF1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name KLF1
Background This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype.
Synonyms: Krueppel-like factor 1,KLF1,EKLF
Molecular Weight 38221 DA
Gene ID 10661
UniProt NP_006554.1, Q13351
Research Area Ubiquitin-related antibodies, Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment KLF1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Zhou, Liu, Sun et al.: "KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching." in: Nature genetics, Vol. 42, Issue 9, pp. 742-4, 2010 (PubMed).

Borg, Papadopoulos, Georgitsi et al.: "Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin." in: Nature genetics, Vol. 42, Issue 9, pp. 801-5, 2010 (PubMed).

Alternatives for antigen "Kruppel-Like Factor 1 (erythroid) (KLF1)", type "Antibodies"
Hosts (14), (10), (6)
Reactivities (27), (8), (4), (4), (3), (1)
Applications (26), (17), (5), (2), (1), (1), (1), (1), (1), (1)
Epitopes (6), (5), (3), (2), (2), (1), (1), (1), (1)
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