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Nonhomologous End-Joining Factor 1 (NHEJ1) (AA 268-296), (C-Term) antibody

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Synonyms NHEJ1, zgc:85657, XLF, 1700029B21Rik, cernunnos
AA 268-296, C-Term
(37), (15), (3), (2), (2), (1), (1)
(87), (6), (6), (5), (3)
(38), (32), (18)
Clonality (Clone)
Polyclonal ()
(3), (3), (3), (3), (3), (3)
Western Blotting (WB)
(79), (32), (27), (19), (13), (13), (10), (2), (1)
Pubmed 3 references available
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Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This NHEJ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 268-296 AA from the C-terminal region of human NHEJ1.
Clone RB34204
Isotype Ig
Specificity This NHEJ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-296 amino acids from the C-terminal region of human NHEJ1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name NHEJ1 (NHEJ1 Antibody Abstract)
Background Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders.
Synonyms: Non-homologous end-joining factor 1,NHEJ1,XLF
Molecular Weight 33337 DA
Gene ID 79840
NCBI Accession NP_079058
UniProt Q9H9Q4
Research Area Transcription Factors, Chromatin, Signaling, Cell Structure
Pathways DNA Damage Repair
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment NHEJ1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Nonhomologous End-Joining Factor 1 (NHEJ1) (AA 268-296), (C-Term) antibody (ABIN658424) NHEJ1 Antibody (C-term) (ABIN658424) western blot analysis in Hela cell line lysates ...
Background publications Malivert, Ropars, Nunez et al.: "Delineation of the Xrcc4-interacting region in the globular head domain of cernunnos/XLF." in: The Journal of biological chemistry, Vol. 285, Issue 34, pp. 26475-83, 2010 (PubMed).

Andres, Modesti, Tsai et al.: "Crystal structure of human XLF: a twist in nonhomologous DNA end-joining." in: Molecular cell, Vol. 28, Issue 6, pp. 1093-101, 2007 (PubMed).

Tsai, Kim, Chu: "Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 19, pp. 7851-6, 2007 (PubMed).

Catalog No. ABIN658424
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