Nonhomologous End-Joining Factor 1 (NHEJ1) (C-Term), (AA 268-296) antibody

Details for Product No. ABIN658424
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Antigen
Synonyms XLF, 1700029B21Rik, cernunnos, NHEJ1, zgc:85657
Epitope
C-Term, AA 268-296
(8), (2), (1), (1)
Reactivity
Human
(33), (4), (4), (4), (2)
Host
Rabbit
(18), (12), (6)
Clonality (Clone)
Polyclonal ()
Application
Western Blotting (WB)
(35), (16), (12), (7), (6), (5), (2), (2)
Pubmed 3 references available
Catalog no. ABIN658424
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This NHEJ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 268-296 AA from the C-terminal region of human NHEJ1.
Clone RB34204
Isotype Ig
Specificity This NHEJ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-296 amino acids from the C-terminal region of human NHEJ1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name NHEJ1
Background Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders.
Synonyms: Non-homologous end-joining factor 1,NHEJ1,XLF
Molecular Weight 33337 DA
Gene ID 79840
UniProt NP_079058.1, Q9H9Q4
Research Area Transcription Factors, Chromatin, Signaling, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment NHEJ1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Nonhomologous End-Joining Factor 1 (NHEJ1) (C-Term), (AA 268-296) antibody NHEJ1 Antibody (C-term) (ABIN658424) western blot analysis in Hela cell line lysates (35 µg/lane). This demonstrates the NHEJ1 antibody detected the NHEJ1 protein (arrow).
Background publications Tsai, Kim, Chu: "Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 19, pp. 7851-6, 2007 (PubMed).

Andres, Modesti, Tsai et al.: "Crystal structure of human XLF: a twist in nonhomologous DNA end-joining." in: Molecular cell, Vol. 28, Issue 6, pp. 1093-101, 2007 (PubMed).

Malivert, Ropars, Nunez et al.: "Delineation of the Xrcc4-interacting region in the globular head domain of cernunnos/XLF." in: The Journal of biological chemistry, Vol. 285, Issue 34, pp. 26475-83, 2010 (PubMed).

Hosts (18), (12), (6)
Reactivities (33), (4), (4), (4), (2)
Applications (35), (16), (12), (7), (6), (5), (2), (2)
Epitopes (8), (2), (1), (1)
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