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Details for Product No. ABIN658424

Nonhomologous End-Joining Factor 1 (NHEJ1) (C-Term), (AA 268-296) antibody

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Antigen
Synonyms XLF, 1700029B21Rik, cernunnos, NHEJ1, zgc:85657
Epitope
»Alternatives C-Term, AA 268-296
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN658424
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This NHEJ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 268-296 AA from the C-terminal region of human NHEJ1.
Clone RB34204
Isotype Ig
Specificity This NHEJ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-296 amino acids from the C-terminal region of human NHEJ1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name NHEJ1
Background Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders.
Synonyms: Non-homologous end-joining factor 1,NHEJ1,XLF
Molecular Weight 33337 DA
Gene ID 79840
UniProt NP_079058.1, Q9H9Q4
Research Area Transcription Factors, Chromatin, Signaling, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment NHEJ1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Tsai, Kim, Chu: "Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 19, pp. 7851-6, 2007 (PubMed).

Andres, Modesti, Tsai et al.: "Crystal structure of human XLF: a twist in nonhomologous DNA end-joining." in: Molecular cell, Vol. 28, Issue 6, pp. 1093-101, 2007 (PubMed).

Malivert, Ropars, Nunez et al.: "Delineation of the Xrcc4-interacting region in the globular head domain of cernunnos/XLF." in: The Journal of biological chemistry, Vol. 285, Issue 34, pp. 26475-83, 2010 (PubMed).

Alternatives for antigen "Nonhomologous End-Joining Factor 1 (NHEJ1)", type "Antibodies"
Hosts (18), (13), (7)
Reactivities (36), (4), (3), (2), (2)
Applications (37), (16), (12), (9), (7), (5), (3), (2)
Epitopes (9), (2), (1), (1)
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