Nonhomologous End-Joining Factor 1 (NHEJ1) (C-Term), (AA 268-296) antibody

Details for Product No. ABIN658424
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Antigen
Synonyms NHEJ1, zgc:85657, XLF, 1700029B21Rik, cernunnos
Epitope
C-Term, AA 268-296
(16), (7), (2), (2), (1), (1)
Reactivity
Human
(47), (4), (4), (4), (2)
Host
Rabbit
(22), (20), (7)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(46), (21), (14), (13), (11), (6), (5), (2), (2)
Pubmed 3 references available
Quantity 400 μL
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Catalog No. ABIN658424
291.50 $
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Immunogen This NHEJ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 268-296 AA from the C-terminal region of human NHEJ1.
Clone RB34204
Isotype Ig
Specificity This NHEJ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 267-296 amino acids from the C-terminal region of human NHEJ1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name NHEJ1
Background Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders.
Synonyms: Non-homologous end-joining factor 1,NHEJ1,XLF
Molecular Weight 33337 DA
Gene ID 79840
NCBI Accession NP_079058
UniProt Q9H9Q4
Research Area Transcription Factors, Chromatin, Signaling, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment NHEJ1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Nonhomologous End-Joining Factor 1 (NHEJ1) (C-Term), (AA 268-296) antibody NHEJ1 Antibody (C-term) (ABIN658424) western blot analysis in Hela cell line lysates (35 µg/lane). This demonstrates the NHEJ1 antibody detected the NHEJ1 protein (arrow).
Background publications Tsai, Kim, Chu: "Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 19, pp. 7851-6, 2007 (PubMed).

Andres, Modesti, Tsai et al.: "Crystal structure of human XLF: a twist in nonhomologous DNA end-joining." in: Molecular cell, Vol. 28, Issue 6, pp. 1093-101, 2007 (PubMed).

Malivert, Ropars, Nunez et al.: "Delineation of the Xrcc4-interacting region in the globular head domain of cernunnos/XLF." in: The Journal of biological chemistry, Vol. 285, Issue 34, pp. 26475-83, 2010 (PubMed).

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