Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3) (N-Term), (AA 73-102) antibody

Details for Product No. ABIN658472
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Antigen
Epitope
N-Term, AA 73-102
(21), (20), (12), (6), (6), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(93), (48), (42), (12), (12), (12)
Host
Rabbit
(88), (11), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(6), (6), (6), (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(62), (54), (43), (20), (19), (10), (9), (6), (4)
Pubmed 2 references available
Quantity 400 μL
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Catalog No. ABIN658472
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Immunogen This EIF2AK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 73-102 AA from the N-terminal region of human EIF2AK3.
Clone RB34502
Isotype Ig
Specificity This EIF2AK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-101 amino acids from the N-terminal region of human EIF2AK3.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name EIF2AK3
Background The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
Synonyms: Eukaryotic translation initiation factor 2-alpha kinase 3,EIF2AK3,PEK, PERK
Molecular Weight 125216 DA
Gene ID 9451
NCBI Accession NP_004827
UniProt Q9NZJ5
Research Area Translation Factors, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Signaling, Chromatin
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment EIF2AK3 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 3 (EIF2AK3) (N-Term), (AA 73-102) antibody EIF2AK3 Antibody (N-term) (ABIN658472) western blot analysis in A549 cell line lysates (35 µg/lane). This demonstrates the EIF2AK3 antibody detected the EIF2AK3 protein (arrow).
Background publications Kim, Moretti, Mitchell et al.: "Endoplasmic reticulum stress mediates radiation-induced autophagy by perk-eIF2alpha in caspase-3/7-deficient cells." in: Oncogene, Vol. 29, Issue 22, pp. 3241-51, 2010 (PubMed).

Lee, Lee, Lee et al.: "Activation of PERK signaling attenuates Abeta-mediated ER stress." in: PLoS ONE, Vol. 5, Issue 5, pp. e10489, 2010 (PubMed).

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