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Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (C-Term), (AA 480-509) antibody

Details for Product No. ABIN658475
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Antigen
Epitope
C-Term, AA 480-509
(15), (13), (9), (7), (5), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(76), (32), (19), (15), (14), (12), (12), (2)
Host
Rabbit
(89), (5)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(6), (6), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(79), (42), (35), (20), (10), (4), (4), (2), (2)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN658475
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Immunogen This RIPK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 480-509 AA from the C-terminal region of human RIPK3.
Clone RB34507
Isotype Ig
Specificity This RIPK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 479-509 amino acids from the C-terminal region of human RIPK3.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name RIPK3
Background The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.
Synonyms: Receptor-interacting serine/threonine-protein kinase 3,RIPK3,RIP3
Molecular Weight 56887 DA
Gene ID 11035
UniProt NP_006862.2, Q9Y572
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Chromatin, Signaling, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment RIPK3 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (C-Term), (AA 480-509) antibody RIPK3 Antibody (C-term) (ABIN658475) western blot analysis in K562 cell line lysates (35 µg/lane). This demonstrates the RIPK3 antibody detected the RIPK3 protein (arrow).
Background publications He, Wang, Miao et al.: "Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha." in: Cell, Vol. 137, Issue 6, pp. 1100-11, 2009 (PubMed).

Goyenechea, Crujeiras, Abete et al.: "Expression of two inflammation-related genes (RIPK3 and RNF216) in mononuclear cells is associated with weight-loss regain in obese subjects." in: Journal of nutrigenetics and nutrigenomics, Vol. 2, Issue 2, pp. 78-84, 2009 (PubMed).

Validation Images
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