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SET (AA 47-75), (N-Term) antibody

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AA 47-75, N-Term
(34), (15), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
(75), (10), (9), (4), (2), (2), (1), (1), (1), (1), (1), (1)
(56), (14), (5)
Clonality (Clone)
Polyclonal ()
(4), (3), (3), (3), (3), (3), (1)
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(68), (35), (26), (15), (10), (9), (9), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Pubmed 4 references available
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Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This SET antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 47-75 AA from the N-terminal region of human SET.
Clone RB34560
Isotype Ig
Specificity This SET antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-75 amino acids from the N-terminal region of human SET.
Predicted Reactivity Fruit Fly (Drosophila melanogaster),Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Background Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone binding. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins, however, isoform 2 specific activity is higher.
Synonyms: Protein SET,SET,
Molecular Weight 33489 DA
Gene ID 6418
NCBI Accession NP_003002, NP_001116293
UniProt Q01105
Research Area Ubiquitin-related antibodies, Signaling, Phospho-specific antibodies, Protein Modifications, Cancer, Chromatin, Cell Structure
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment SET Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-SET (AA 47-75), (N-Term) antibody (ABIN658502) SET Antibody (N-term) (ABIN658502) western blot analysis in Jurkat cell line lysates ...
Background publications Kim, Kim, Kim et al.: "Negative regulation of neuronal cell differentiation by INHAT subunit SET/TAF-Iβ." in: Biochemical and biophysical research communications, Vol. 400, Issue 3, pp. 419-25, 2010 (PubMed).

Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).

Chao, Tsai, Wei et al.: "Decreased expression of microRNA-199b increases protein levels of SET (protein phosphatase 2A inhibitor) in human choriocarcinoma." in: Cancer letters, Vol. 291, Issue 1, pp. 99-107, 2010 (PubMed).

Kajiwara, Akram, Katsel et al.: "FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4." in: PLoS ONE, Vol. 4, Issue 4, pp. e5071, 2009 (PubMed).

Catalog No. ABIN658502
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