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Details for Product No. ABIN658504

U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59) (N-Term), (AA 1-30) antibody

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Synonyms u2af65, 65kDa, U2AF65, U2AF2, DDBDRAFT_0186947, DDBDRAFT_0233353, DDB_0186947, DDB_0233353
»Alternatives N-Term, AA 1-30
»Alternatives Human
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN658504
Quantity 400 µL
291.50 $   Plus shipping costs $45.00
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Immunogen This U2AF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human U2AF2.
Clone RB34565
Isotype Ig
Specificity This U2AF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human U2AF2.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name U2AF2
Background U2 auxiliary factor (U2AF), comprised of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of introns early during spliceosome assembly. Multiple transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date. [provided by RefSeq].
Synonyms: Splicing factor U2AF 65 kDa subunit,U2AF2,U2AF65
Molecular Weight 53501 DA
Gene ID 11338
UniProt NP_001012496.1, P26368, NP_009210.1
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment U2AF2 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Izquierdo: "Fas splicing regulation during early apoptosis is linked to caspase-mediated cleavage of U2AF65." in: Molecular biology of the cell, Vol. 19, Issue 8, pp. 3299-307, 2008 (PubMed).

Jenkins, Shen, Green et al.: "Solution conformation and thermodynamic characteristics of RNA binding by the splicing factor U2AF65." in: The Journal of biological chemistry, Vol. 283, Issue 48, pp. 33641-9, 2008 (PubMed).

Webby, Wolf, Gromak et al.: "Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing." in: Science (New York, N.Y.), Vol. 325, Issue 5936, pp. 90-3, 2009 (PubMed).

Alternatives for antigen "U2 Small Nuclear RNA Auxiliary Factor 2 (U2AF59)", type "Antibodies"
Hosts (13), (1)
Reactivities (13), (3), (3), (1), (1), (1), (1)
Applications (14), (5), (2)
Epitopes (4), (2), (2)