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Neural Precursor Cell Expressed, Developmentally Down-Regulated 9 (NEDD9) (AA 335-363), (Center) antibody

Details for Product No. ABIN658513, Supplier: Login to see
Antigen
  • NEDD9
  • CAS-L
  • CAS2
  • CASL
  • CASS2
  • HEF1
  • Cas-L
  • CasL
  • E230025G09Rik
Epitope
AA 335-363, Center
20
11
10
9
4
4
4
3
3
2
1
1
1
1
1
Reactivity
Human
67
16
13
5
2
1
1
1
Host
Rabbit
35
17
15
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
2
2
2
2
2
2
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
60
31
20
13
10
5
2
2
2
1
Supplier
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Immunogen This NEDD9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 335-363 AA from the Central region of human NEDD9.
Clone RB34579
Isotype Ig
Specificity This NEDD9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 334-363 amino acids from the Central region of human NEDD9.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name NEDD9 (NEDD9 Antibody Abstract)
Background Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B-and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form.
Synonyms: Enhancer of filamentation 1,NEDD9,CASL, CASS2
Molecular Weight 92861 DA
Gene ID 4739
NCBI Accession NP_892011, NP_006394
UniProt Q14511
Research Area Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Cell Cycle
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment NEDD9 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 9 (NEDD9) (AA 335-363), (Center) antibody (ABIN658513) NEDD9 Antibody (Center) (ABIN658513) western blot analysis in MCF-7 cell line lysates...
Background publications Corneveaux, Myers, Allen et al.: "Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals." in: Human molecular genetics, Vol. 19, Issue 16, pp. 3295-301, 2010 (PubMed).

Lucas, Salimath, Slomiany et al.: "Regulation of invasive behavior by vascular endothelial growth factor is HEF1-dependent." in: Oncogene, Vol. 29, Issue 31, pp. 4449-59, 2010 (PubMed).