Neural Precursor Cell Expressed, Developmentally Down-Regulated 9 (NEDD9) (AA 335-363), (Center) antibody

Details for Product No. ABIN658513
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Antigen
Synonyms NEDD9, CAS-L, CAS2, CASL, CASS2, HEF1, Cas-L, CasL, E230025G09Rik
Epitope
AA 335-363, Center
(10), (6), (4), (4), (3), (3), (1), (1), (1), (1)
Reactivity
Human
(50), (24), (21), (15), (12)
Host
Rabbit
(32), (16), (5)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(38), (15), (14), (13), (10), (10), (9), (5), (3), (3), (2)
Pubmed 2 references available
Quantity 400 μL
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Catalog No. ABIN658513
291.50 $
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Immunogen This NEDD9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 335-363 AA from the Central region of human NEDD9.
Clone RB34579
Isotype Ig
Specificity This NEDD9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 334-363 amino acids from the Central region of human NEDD9.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name NEDD9
Background Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signaling in B-and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form.
Synonyms: Enhancer of filamentation 1,NEDD9,CASL, CASS2
Molecular Weight 92861 DA
Gene ID 4739
NCBI Accession NP_892011, NP_006394
UniProt Q14511
Research Area Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Cell Cycle
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment NEDD9 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Neural Precursor Cell Expressed, Developmentally Down-Regulated 9 (NEDD9) (AA 335-363), (Center) antibody NEDD9 Antibody (Center) (ABIN658513) western blot analysis in MCF-7 cell line lysates (35 µg/lane). This demonstrates the NEDD9 antibody detected the NEDD9 protein (arrow).
Background publications Lucas, Salimath, Slomiany et al.: "Regulation of invasive behavior by vascular endothelial growth factor is HEF1-dependent." in: Oncogene, Vol. 29, Issue 31, pp. 4449-59, 2010 (PubMed).

Corneveaux, Myers, Allen et al.: "Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals." in: Human molecular genetics, Vol. 19, Issue 16, pp. 3295-301, 2010 (PubMed).

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