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Activin Receptor Type IC (ACVR1C) (AA 341-368), (C-Term) antibody

Details for Product No. ABIN658527, Supplier: Login to see
Antigen
  • ACVRLK7
  • ALK7
  • Alk-7
  • C230097P10
  • Alk7
  • habrec1
Epitope
AA 341-368, C-Term
16
15
15
13
4
4
3
2
1
1
1
1
1
1
1
1
1
Reactivity
Mouse (Murine)
67
58
36
Host
Rabbit
81
8
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
3
3
3
3
2
2
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
60
37
15
12
11
3
2
2
1
Supplier
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Immunogen This Mouse Acvr1c antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-368 AA from the C-terminal region of mouse Acvr1c.
Clone RB34725
Isotype Ig
Specificity This Mouse Acvr1c antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 340-368 amino acids from the C-terminal region of Mouse Acvr1c.
Predicted Reactivity Human,Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Acvr1c (ACVR1C Antibody Abstract)
Background Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Synonyms: Activin receptor type-1C,Acvr1c,Alk7
Molecular Weight 54684 DA
Gene ID 269275
NCBI Accession NP_001104500
UniProt Q8K348
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Chromatin, Signaling
Pathways
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Mouse Acvr1c Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Activin Receptor Type IC (ACVR1C) (AA 341-368), (C-Term) antibody (ABIN658527) Mouse Acvr1c Antibody (C-term) (ABIN658527) western blot analysis in mouse heart tiss...
Product cited in: Huang, Tang, Wu et al.: "ALK7 protects against pathological cardiac hypertrophy in mice." in: Cardiovascular research, Vol. 108, Issue 1, pp. 50-61, 2015 (PubMed).

Background publications Andersson, Korach-Andre, Reissmann et al.: "Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 20, pp. 7252-6, 2008 (PubMed).

Bertolino, Holmberg, Reissmann et al.: "Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 20, pp. 7246-51, 2008 (PubMed).

Liguori, Borges, DAndrea et al.: "Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo." in: Developmental biology, Vol. 315, Issue 2, pp. 280-9, 2008 (PubMed).

Kurrasch, Cheung, Lee et al.: "The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 50, pp. 13624-34, 2007 (PubMed).