Activin Receptor Type IC (ACVR1C) (C-Term), (AA 341-368) antibody

Details for Product No. ABIN658527
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Antigen
Synonyms ACVRLK7, ALK7, Alk-7, C230097P10, Alk7, habrec1
Epitope
C-Term, AA 341-368
(12), (7), (7), (3), (2), (1), (1), (1), (1)
Reactivity
Mouse (Murine)
(51), (45), (36), (17), (17), (17)
Host
Rabbit
(58), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(40), (23), (14), (11), (7), (2), (2), (1), (1)
Pubmed 4 references available
Quantity 400 µL
Options
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Catalog No. ABIN658527
291.50 $
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Immunogen This Mouse Acvr1c antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-368 AA from the C-terminal region of mouse Acvr1c.
Clone RB34725
Isotype Ig
Specificity This Mouse Acvr1c antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 340-368 amino acids from the C-terminal region of Mouse Acvr1c.
Predicted Reactivity Human,Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Acvr1c
Background Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Synonyms: Activin receptor type-1C,Acvr1c,Alk7
Molecular Weight 54684 DA
Gene ID 269275
NCBI Accession NP_001104500
UniProt Q8K348
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Chromatin, Signaling
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Mouse Acvr1c Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Supplier Images
anti-Activin Receptor Type IC (ACVR1C) (C-Term), (AA 341-368) antibody Mouse Acvr1c Antibody (C-term) (ABIN658527) western blot analysis in mouse heart tissue lysates (35 µg/lane). This demonstrates the Acvr1c antibody detected the Acvr1c protein (arrow).
Background publications Kurrasch, Cheung, Lee et al.: "The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 50, pp. 13624-34, 2007 (PubMed).

Liguori, Borges, DAndrea et al.: "Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo." in: Developmental biology, Vol. 315, Issue 2, pp. 280-9, 2008 (PubMed).

Bertolino, Holmberg, Reissmann et al.: "Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 20, pp. 7246-51, 2008 (PubMed).

Andersson, Korach-Andre, Reissmann et al.: "Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 20, pp. 7252-6, 2008 (PubMed).

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