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Details for Product No. ABIN658527

Activin Receptor Type IC (ACVR1C) (C-Term), (AA 341-368) antibody

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Antigen
Synonyms ALK7, Alk-7, ACVRLK7, C230097P10, Alk7, habrec1
Epitope
»Alternatives C-Term, AA 341-368
Reactivity
»Alternatives Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 4 references available
Catalog no. ABIN658527
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This Mouse Acvr1c antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-368 AA from the C-terminal region of mouse Acvr1c.
Clone RB34725
Isotype Ig
Specificity This Mouse Acvr1c antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 340-368 amino acids from the C-terminal region of Mouse Acvr1c.
Predicted Reactivity Human,Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Acvr1c
Background Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Synonyms: Activin receptor type-1C,Acvr1c,Alk7
Molecular Weight 54684 DA
Gene ID 269275
UniProt Q8K348, NP_001104500.1
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Chromatin, Signaling
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Mouse Acvr1c Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Expiry Date 6 months
Background publications Kurrasch, Cheung, Lee et al.: "The neonatal ventromedial hypothalamus transcriptome reveals novel markers with spatially distinct patterning." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 50, pp. 13624-34, 2007 (PubMed).

Liguori, Borges, DAndrea et al.: "Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo." in: Developmental biology, Vol. 315, Issue 2, pp. 280-9, 2008 (PubMed).

Bertolino, Holmberg, Reissmann et al.: "Activin B receptor ALK7 is a negative regulator of pancreatic beta-cell function." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 20, pp. 7246-51, 2008 (PubMed).

Andersson, Korach-Andre, Reissmann et al.: "Growth/differentiation factor 3 signals through ALK7 and regulates accumulation of adipose tissue and diet-induced obesity." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 20, pp. 7252-6, 2008 (PubMed).

Alternatives for antigen "Activin Receptor Type IC (ACVR1C)", type "Antibodies"
Hosts (50), (2)
Reactivities (48), (36), (33), (17), (17), (17)
Applications (32), (17), (15), (10), (9), (6), (2), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (11), (3), (2), (2), (2), (1), (1), (1)
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