ADP-Ribosylation Factor GTPase Activating Protein 1 (ARFGAP1) (Center) antibody

Antigen: ADP-Ribosylation Factor GTPase Activating Protein 1 (ARFGAP1)

Synonyms: DKFZp564M0264, AI788669, AW496366, MGC102530, ARFGAP1, FLJ45618, ARF1GAP, MGC39924, HRIHFB2281, MGC72830, Arfgap1, 0610009H19Rik, 1810004P07Rik, 1810035F16Rik, 9130416J18Rik, wu:fb33e02, wu:fb78h01, Arf1gap, AI115377, Arf GAP1, MGC53624, arf2, MGC52628, arf-1, MGC52573, arf6, MGC76053, ARF1, MGC80156, arfgap1, MGC83573, MGC79593, ARFGAP3, ADP-RIBOSYLATION FACTOR, ADP-RIBOSYLATION FACTOR 1, ADP-RIBOSYLATION FACTOR 1A, ATARF, ATARF1, ATARFA1A, F28C11.12, lqt, rws, wrs, lqt1, sqt2, atfb1, atfb3, jlns1, kcna8, kcna9, kv1.9, kv7.1, kvlqt1, arf1gap, k(v)7.1, GAP, PKWS, RASA, CMAVM, CM-AVM, RASGAP, p120GAP, p120RASGAP, DKFZp434N071, CDHP, HJMD, PCAD

Binding Site: Center

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN658568

Additional Information

Alternative name: ARFGAP1

Isotype: Ig

Description: Other names: ADP-ribosylation factor GTPase-activating protein 1,ARFGAP1,ARF1GAP

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This ARFGAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 237-267 amino acids from the Central region of human ARFGAP1.

Comments:

Background: The protein encoded by this gene is a GTPase-activating protein (GAP) which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1 (ARF1). The encoded protein promotes hydrolysis of ARF1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Two transcript variants encoding different isoforms have been found for this gene.

Synonyms: DKFZp564M0264, AI788669, AW496366, MGC102530, ARFGAP1, FLJ45618, ARF1GAP, MGC39924, HRIHFB2281, MGC72830, Arfgap1, 0610009H19Rik, 1810004P07Rik, 1810035F16Rik, 9130416J18Rik, wu:fb33e02, wu:fb78h01, Arf1gap, AI115377, Arf GAP1, MGC53624, arf2, MGC52628, arf-1, MGC52573, arf6, MGC76053, ARF1, MGC80156, arfgap1, MGC83573, MGC79593, ARFGAP3, ADP-RIBOSYLATION FACTOR, ADP-RIBOSYLATION FACTOR 1, ADP-RIBOSYLATION FACTOR 1A, ATARF, ATARF1, ATARFA1A, F28C11.12, lqt, rws, wrs, lqt1, sqt2, atfb1, atfb3, jlns1, kcna8, kcna9, kv1.9, kv7.1, kvlqt1, arf1gap, k(v)7.1, GAP, PKWS, RASA, CMAVM, CM-AVM, RASGAP, p120GAP, p120RASGAP, DKFZp434N071, CDHP, HJMD, PCAD

Application Details

Concentration: 0.25 mg/ml

Purification: Purified

Research Area: Signaling, Phospho-specific antibodies, Protein Modifications, Cell Structure

Restrictions: For Research Use only

Images

ARFGAP1 Antibody (Center) (ABIN658568) western blot analysis in 293 cell line lysates (35ug/lane). This demonstrates the ARFGAP1 antibody detected the ARFGAP1 protein (arrow).

Publications

Product: Lamesch, Li, Milstein et al.: "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes." in: Genomics, Vol. 89, Issue 3, pp. 307-15, 2007 (PubMed).

Luo, Randazzo: "Kinetic analysis of Arf GAP1 indicates a regulatory role for coatomer." in: The Journal of biological chemistry, Vol. 283, Issue 32, pp. 21965-77, 2008 (PubMed).

Saitoh, Shin, Yamada et al.: "Three homologous ArfGAPs participate in coat protein I-mediated transport." in: The Journal of biological chemistry, Vol. 284, Issue 20, pp. 13948-57, 2009 (PubMed).