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Details for Product No. ABIN658577

Chromobox Homolog 8 (CBX8) (AA 161-189), (Center) antibody

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Antigen
Synonyms PC3, RC1, Pc3, cbx8, MGC147589
Epitope
»Alternatives AA 161-189, Center
Reactivity
»Alternatives Mouse (Murine)
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN658577
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This CBX8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-189 AA from the Central region of human CBX8.
Clone RB34333
Isotype Ig
Specificity This CBX8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-189 amino acids from the Central region of human CBX8.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CBX8
Background Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Synonyms: Chromobox protein homolog 8,CBX8,PC3, RC1
Research Area Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.35 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Background publications Stelzl, Worm, Lalowski et al.: "A human protein-protein interaction network: a resource for annotating the proteome." in: Cell, Vol. 122, Issue 6, pp. 957-68, 2005 (PubMed).

Olsen, Blagoev, Gnad et al.: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Dietrich, Bracken, Trinh et al.: "Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus." in: The EMBO journal, Vol. 26, Issue 6, pp. 1637-48, 2007 (PubMed).

Alternatives for antigen "Chromobox Homolog 8 (CBX8)", type "Antibodies"
Hosts (32), (14), (6)
Reactivities (49), (22), (16), (15), (15), (12), (2), (2), (1)
Applications (42), (17), (11), (10), (4), (2), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (7), (5), (2), (2), (2), (2), (2), (1), (1)
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