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CBX8 antibody (Chromobox Homolog 8) (AA 161-189)

Details for Product anti-CBX8 Antibody No. ABIN658577, Supplier: Log in to see
Antigen
  • cbx8
  • MGC147589
  • Pc3
  • PC3
  • RC1
  • chromobox homolog 8
  • chromobox 8
  • chromobox homolog 8a (Pc class homolog, Drosophila)
  • cbx8
  • CBX8
  • Cbx8
  • cbx8a
Epitope
AA 161-189, Center
24
20
18
15
8
8
3
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Mouse (Murine)
125
55
22
9
7
5
5
4
3
3
2
2
2
2
1
Host
Rabbit
68
49
17
Clonality (Clone)
Polyclonal ()
Conjugate
This CBX8 antibody is un-conjugated
5
5
5
5
5
5
Application
Western Blotting (WB)
116
59
38
13
13
10
3
3
2
1
1
1
Options
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Immunogen This CBX8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-189 AA from the Central region of human CBX8.
Clone RB34333
Isotype Ig
Specificity This CBX8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 160-189 amino acids from the Central region of human CBX8.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CBX8 (CBX8 Antibody Abstract)
Background Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
Synonyms: Chromobox protein homolog 8,CBX8,PC3, RC1
Research Area Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.35 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Western Blotting (WB) image for anti-CBX8 antibody (Chromobox Homolog 8) (AA 161-189) (ABIN658577) CBX8 Antibody (Center) (ABIN658577) western blot analysis in mouse liver tissue lysat...
Background publications Dietrich, Bracken, Trinh, Schjerling, Koseki, Rappsilber, Helin, Hansen: "Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus." in: The EMBO journal, Vol. 26, Issue 6, pp. 1637-48, 2007 (PubMed).

Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, 2006 (PubMed).

Stelzl, Worm, Lalowski, Haenig, Brembeck, Goehler, Stroedicke, Zenkner, Schoenherr, Koeppen, Timm, Mintzlaff, Abraham, Bock, Kietzmann, Goedde, Toksöz, Droege, Krobitsch, Korn, Birchmeier, Lehrach et al.: "A human protein-protein interaction network: a resource for annotating the proteome. ..." in: Cell, Vol. 122, Issue 6, pp. 957-68, 2005 (PubMed).