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Epidermal Growth Factor Receptor (EGFR) (C-Term,Ser1081) antibody
Alternatives Western Blotting (WB), ELISA
|2 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Description||Other names: Epidermal growth factor receptor,EGFR,ERBB1|
|Characteristics||Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This EGFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human EGFR.|
Background: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
|Synonyms||ERBB, HER1, mENA, ERBB1, PIG61, Wa5, wa2, Erbb, Errp, wa-2, AI552599, 9030024J15Rik, ErbB-1, C-erb, D-EGFR, D-Egf, DEGFR, DER, DER flb, DER/EGFR, DER/faint little ball, DER/top, DER/torpedo, DmHD-33, EFG-R, EGF-R, EGFR, EK2-6, Egf, El, Elp, Elp-1, Elp-B1, Elp-B1RB1, HD-33, Torpedo/DER, Torpedo/Egfr, c-erbB, d-egf-r, dEGFR1, flb, l(2)05351, l(2)09261, l(2)57DEFa, l(2)57EFa, l(2)57Ea, pnt, top, top/DER, top/flb, DmelCG10079, CG10079, egfr, EGFR12, EGFR15, egfr1, Erbb2|
|Research Area||Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Cancer, Signaling, Chromatin|
|Restrictions||For Research Use only|
|EGFR Antibody (C-term S1081) (ABIN658590) western blot analysis in mouse lung tissue lysates (35ug/lane). This demonstrates the EGFR antibody detected the EGFR protein (arrow).|
Abdallah, Keum, El-Shewy et al.: "Plasma kallikrein promotes epidermal growth factor receptor transactivation and signaling in vascular smooth muscle through direct activation of protease-activated receptors." in: The Journal of biological chemistry, Vol. 285, Issue 45, pp. 35206-15, 2010 (PubMed).
Aguirre, Rubio, Gallo: "Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal." in: Nature, Vol. 467, Issue 7313, pp. 323-7, 2010 (PubMed).