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Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3) (AA 239-268), (Center) antibody

Details for Product No. ABIN658606, Supplier: Log in to see
Antigen
  • Kv1.3-glyb
  • kv1.3
  • Kv1.3B
  • kcna3b-a
  • HGK5
  • HLK3
  • HPCN3
  • HUKIII
  • KV1.3
  • MK3
  • PCN3
  • Kca1-3
  • Kv1.3
  • Mk-3
  • cKv1.1
Epitope
AA 239-268, Center
19
18
16
11
7
5
4
4
4
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
89
43
41
4
4
4
4
2
Host
Rabbit
82
9
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
4
4
3
3
2
2
2
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
60
31
20
13
12
10
3
2
2
1
1
Supplier
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Immunogen This KCNA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-268 AA from the Central region of human KCNA3.
Clone RB34612
Isotype Ig
Specificity This KCNA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 238-268 amino acids from the Central region of human KCNA3.
Predicted Reactivity Mouse (Murine),Rat (Rattus)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name KCNA3 (KCNA3 Antibody Abstract)
Background Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1.
Synonyms: Potassium voltage-gated channel subfamily A member 3,KCNA3,HGK5
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Western Blotting (WB) image for anti-Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 3 (KCNA3) (AA 239-268), (Center) antibody (ABIN658606) KCNA3 Antibody (Center) (ABIN658606) western blot analysis in A549 cell line lysates ...
Background publications Wang, Lee, Johnson et al.: "Activated T-cells inhibit neurogenesis by releasing granzyme B: rescue by Kv1.3 blockers." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 14, pp. 5020-7, 2010 (PubMed).

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