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Details for Product No. ABIN658616

Mediator Complex Subunit 6 (MED6) (AA 135-164), (Center) antibody

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Antigen
Synonyms 1500012F11Rik, AU019660, AV213303, NY-REN-28
Epitope
»Alternatives AA 135-164, Center
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Application
»Alternatives Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN658616
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This MED6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 135-164 AA from the Central region of human MED6.
Clone RB20183
Isotype Ig
Specificity This MED6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-164 amino acids from the Central region of human MED6.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name MED6
Background Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Synonyms: Mediator of RNA polymerase II transcription subunit 6,MED6,ARC33
Research Area Translation Factors, Signaling, Protein Modifications, Transcription Factors, Cell Structure
Application Notes Recommend dilutions: WB : 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Background publications Sato, Tomomori-Sato, Banks et al.: "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex." in: The Journal of biological chemistry, Vol. 278, Issue 50, pp. 49671-4, 2003 (PubMed).

Tomomori-Sato, Sato, Parmely et al.: "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2." in: The Journal of biological chemistry, Vol. 279, Issue 7, pp. 5846-51, 2004 (PubMed).

Yang, DeBeaumont, Zhou et al.: "The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 8, pp. 2339-44, 2004 (PubMed).

Sato, Tomomori-Sato, Parmely et al.: "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology." in: Molecular cell, Vol. 14, Issue 5, pp. 685-91, 2004 (PubMed).

Pavri, Lewis, Kim et al.: "PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator." in: Molecular cell, Vol. 18, Issue 1, pp. 83-96, 2005 (PubMed).

Alternatives for antigen "Mediator Complex Subunit 6 (MED6)", type "Antibodies"
Hosts (16), (7)
Reactivities (23), (6), (5), (3), (3), (2), (1), (1), (1), (1)
Applications (23), (9), (4), (2)
Epitopes (5), (5), (3), (3), (2), (2), (2), (2), (1), (1)
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