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Mediator Complex Subunit 6 (MED6) (AA 135-164), (Center) antibody

Details for Product No. ABIN658616, Supplier: Log in to see
Antigen
  • 1500012F11Rik
  • AU019660
  • AV213303
  • NY-REN-28
  • wu:fa14c11
  • zgc:86933
Epitope
AA 135-164, Center
19
16
16
15
9
8
5
3
2
2
1
1
1
Reactivity
Human
72
10
9
2
2
2
Host
Rabbit
58
14
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
4
4
4
4
4
4
Application
Western Blotting (WB)
66
37
3
2
2
2
Supplier
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Immunogen This MED6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 135-164 AA from the Central region of human MED6.
Clone RB20183
Isotype Ig
Specificity This MED6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-164 amino acids from the Central region of human MED6.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name MED6 (MED6 Antibody Abstract)
Background Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Synonyms: Mediator of RNA polymerase II transcription subunit 6,MED6,ARC33
Research Area Translation Factors, Signaling, Protein Modifications, Transcription Factors, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Western Blotting (WB) image for anti-Mediator Complex Subunit 6 (MED6) (AA 135-164), (Center) antibody (ABIN658616) MED6 Antibody (Center) (ABIN658616) western blot analysis in WiDr cell line lysates (...
Background publications Pavri, Lewis, Kim, Dilworth, Erdjument-Bromage, Tempst, de Murcia, Evans, Chambon, Reinberg: "PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator." in: Molecular cell, Vol. 18, Issue 1, pp. 83-96, 2005 (PubMed).

Sato, Tomomori-Sato, Parmely, Florens, Zybailov, Swanson, Banks, Jin, Cai, Washburn, Conaway, Conaway: "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology." in: Molecular cell, Vol. 14, Issue 5, pp. 685-91, 2004 (PubMed).

Yang, DeBeaumont, Zhou, Näär: "The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 8, pp. 2339-44, 2004 (PubMed).

Tomomori-Sato, Sato, Parmely, Banks, Sorokina, Florens, Zybailov, Washburn, Brower, Conaway, Conaway: "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2." in: The Journal of biological chemistry, Vol. 279, Issue 7, pp. 5846-51, 2004 (PubMed).

Sato, Tomomori-Sato, Banks, Parmely, Sorokina, Brower, Conaway, Conaway: "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex." in: The Journal of biological chemistry, Vol. 278, Issue 50, pp. 49671-4, 2003 (PubMed).