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V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) (N-Term) antibody

Antigen

V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1)
Synonyms
AKT, PKB, RAC, PRKBA, MGC99656, PKB-ALPHA, RAC-ALPHA, Akt, pkb, xAct, akt-1, v-akt, v-akt1, AKT1, AKT/PKB, D-Akt, DAKT1, DAKT1/PKB, DPKB, DRAC-PK, DRAC-PK66; DRAC-PK85, Dakt, PKB/AKT, PKB/dAKT, RacPK, ... show more
Binding Site
Alternatives

N-Term
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Mouse (Murine)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), ELISA
3 references available
Certificates ISO 9001:2008
Catalog no. ABIN658621
Quantity 0.1 mg  (0.25 mg/ml)  (Variants)
Price 280.50 $   Plus shipping costs $45.00
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anti-V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) (N-Term) antibody

Additional Information
Application Details Publications Images Alternatives Variants back to top

Alternative name Akt1
Isotype Ig
Description Other names: RAC-alpha serine/threonine-protein kinase,Akt1,Akt, Rac
Characteristics Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Specificity This Mouse Akt1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-49 amino acids from the N-terminal region of Mouse Akt1.
Comments

Background: This gene encodes the founding member of the Akt serine-threonine protein kinase gene family that also includes Akt2 and Akt3. This kinase is a major downstream effector of the phosphatidylinositol 3-kinase (PI3K) pathway that mediates the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). It is activated through recruitment to cellular membranes by PI3K lipid products and by phosphorylation by 3-phosphoinositide dependent kinase-1. It then further phosphorylates different downstream proteins in response to various extracellular signals and thus plays a pivotal role in mediating a variety of cellular processes, such as glucose metabolism, glycogen biosynthesis, protein synthesis and turn over, inflammatory response, cell survival (anti-apoptosis) and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Synonyms AKT, PKB, RAC, PRKBA, MGC99656, PKB-ALPHA, RAC-ALPHA, Akt, pkb, xAct, akt-1, v-akt, v-akt1, AKT1, AKT/PKB, D-Akt, DAKT1, DAKT1/PKB, DPKB, DRAC-PK, DRAC-PK66; DRAC-PK85, Dakt, PKB/AKT, PKB/dAKT, RacPK, dAKT/dPKB, dAkt/PKB, l(3)04226, l(3)89Bq, DmelCG4006, CG4006

Publications
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Product Zhou, Chang, Zhang et al.: "Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development." in: The American journal of pathology, Vol. 177, Issue 4, pp. 2124-33, 2010 (PubMed).

Chang, Zhang, Feng et al.: "Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation." in: Developmental biology, Vol. 347, Issue 2, pp. 384-91, 2010 (PubMed).

Sun, Xie, Yang et al.: "Endocannabinoid signaling directs differentiation of trophoblast cell lineages and placentation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 39, pp. 16887-92, 2010 (PubMed).

Alternatives
Application Details Publications Images Variants back to top

Alternatives for antigen "V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1)", type "Antibodies"
Hosts Rabbit (358), Mouse (95), Sheep (6), Goat (3), Chicken (1)
Reactivities Human (453), Mouse (Murine) (276), Rat (Rattus) (273), Chicken (114), Dog (Canine) (111), Cow (Bovine) (93), Sheep (Ovine) (88), Pig (Porcine) (83), Rabbit (37), Monkey (21), Chimpanzee (5), Horse (Equine) (5), Cat (Feline) (4), Chemical (3), Xenopus laevis (2), Arabidopsis thaliana (1), Frog (1)
Applications Western Blotting (WB) (335), ELISA (218), Immunofluorescence (IF) (151), Immunohistochemistry (IHC) (116), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (84), Flow Cytometry (FACS) (77), Immunoprecipitation (IP) (39), Immunocytochemistry (ICC) (20), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (12), Dot Blot (Dot) (7), Fluorescence Microscopy (FM) (5), Immunoelectron Microscopy (IEM) (4), Immunohistochemistry (Frozen Sections) (IHC (fro)) (4), Immunohistochemistry (Fixed) (IHC (fx)) (2), Dot Blot (DB) (1)
Conjugates Biotin (12), Alexa Fluor 350 (9), Alexa Fluor 488 (9), Alexa Fluor 555 (9), Alexa Fluor 647 (9), PE,Cy5.5 (7), HRP (5), PE (5), Cy3 (4), Cy5 (4), Cy5.5 (4), Cy7 (4), FITC (4), Gold (4), PE,Cy3 (2), PE,Cy5 (2), PE,Cy7 (2), PE-Cy3 (2), PE-Cy5 (2), PE-Cy5.5 (2), PE-Cy7 (2), Un-conjugated (2), APC (1), Agarose Beads (1), Atto 594 (1), CF (1), Sepharose (1)
Epitopes pSer473 (39), pThr308 (28), C-Term (21), pTyr474 (19), pSer473,pTyr474 (18), N-Term (14), pThr450 (12), Internal Region (8), pSer129 (8), Ser473 (7), pTyr326 (7), Thr308 (6), pSer124 (4), pThr34 (4), Ser124 (3), Ser129 (3), Thr450 (3), pSer246 (3), AA 460-480 (2), Ser246 (2), pSer473,Internal Region (2), AA 2-480 (1), AA 302-311,pThr308 (1), AA 460-480,C-Term, pSer473 (1), AA 464-477 (1), AA 74-89 (1), AA 80 (1), C-Term,Thr450 (1), N-Term,Gly37 (1), Phosphospecific (1), Tyr326 (1), pSer269 (1), pSer308 (1), pThr308,Internal Region (1), pThr500 (1), pThr72 (1), pTyr204 (1), pTyr312,pTyr316,pTyr315 (1)