|+1 404 474 4654|
|+1 888 205 9894 (TF)|
V-Akt Murine Thymoma Viral Oncogene Homolog 1 (AKT1) (N-Term) antibody
Alternatives Western Blotting (WB), ELISA
|3 references available|
|Quantity||0.1 mg (0.25 mg/ml) (Variants)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Description||Other names: RAC-alpha serine/threonine-protein kinase,Akt1,Akt, Rac|
|Characteristics||Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This Mouse Akt1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-49 amino acids from the N-terminal region of Mouse Akt1.|
Background: This gene encodes the founding member of the Akt serine-threonine protein kinase gene family that also includes Akt2 and Akt3. This kinase is a major downstream effector of the phosphatidylinositol 3-kinase (PI3K) pathway that mediates the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). It is activated through recruitment to cellular membranes by PI3K lipid products and by phosphorylation by 3-phosphoinositide dependent kinase-1. It then further phosphorylates different downstream proteins in response to various extracellular signals and thus plays a pivotal role in mediating a variety of cellular processes, such as glucose metabolism, glycogen biosynthesis, protein synthesis and turn over, inflammatory response, cell survival (anti-apoptosis) and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
|Synonyms||AKT, PKB, RAC, PRKBA, MGC99656, PKB-ALPHA, RAC-ALPHA, Akt, pkb, xAct, akt-1, v-akt, v-akt1, AKT1, AKT/PKB, D-Akt, DAKT1, DAKT1/PKB, DPKB, DRAC-PK, DRAC-PK66; DRAC-PK85, Dakt, PKB/AKT, PKB/dAKT, RacPK, dAKT/dPKB, dAkt/PKB, l(3)04226, l(3)89Bq, DmelCG4006, CG4006|
|Research Area||Translation Factors, Protein Modifications, Signaling, Neurology, Cell Structure, Ubiquitin-related antibodies, Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Chromatin, Metabolism|
|Restrictions||For Research Use only|
|Mouse Akt1 Antibody (N-term) (ABIN658621) western blot analysis in mouse heart tissue lysates (35ug/lane). This demonstrates the Akt1 antibody detected the Akt1 protein (arrow).|
Zhou, Chang, Zhang et al.: "Akt/Protein kinase B is required for lymphatic network formation, remodeling, and valve development." in: The American journal of pathology, Vol. 177, Issue 4, pp. 2124-33, 2010 (PubMed).
Chang, Zhang, Feng et al.: "Deletion of Akt1 causes heart defects and abnormal cardiomyocyte proliferation." in: Developmental biology, Vol. 347, Issue 2, pp. 384-91, 2010 (PubMed).
Sun, Xie, Yang et al.: "Endocannabinoid signaling directs differentiation of trophoblast cell lineages and placentation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 39, pp. 16887-92, 2010 (PubMed).