Disrupted in Schizophrenia 1 (DISC1) (C-Term), (AA 701-728) antibody

Details for Product No. ABIN658716
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Antigen
Epitope
C-Term, AA 701-728
(34), (32), (17), (6), (6), (6), (5), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(107), (47), (15)
Host
Rabbit
(111), (7), (5), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Application
Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC)
(103), (50), (34), (25), (20), (11), (6), (3), (3)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN658716
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Immunogen This DISC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 701-728 AA from the C-terminal region of human DISC1.
Clone RB31996
Isotype Ig
Specificity This DISC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 700-728 amino acids from the C-terminal region of human DISC1.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name DISC1
Background This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1,11)(q42.1,q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].
Synonyms: Disrupted in schizophrenia 1 protein,DISC1,KIAA0457
Research Area Cell Signaling, Signaling, Chromatin, Neurology, Cell Structure
Application Notes WB = 1:1000, FACS = 1:10-50, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.39 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
anti-Disrupted in Schizophrenia 1 (DISC1) (C-Term), (AA 701-728) antibody DISC1 Antibody (C-term) (ABIN658716) western blot analysis in Ramos cell line lysates (35 µg/lane). This demonstrates the DISC1 antibody detected the DISC1 protein (arrow).
Background publications Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

Raznahan, Lee, Long et al.: "Common functional polymorphisms of DISC1 and cortical maturation in typically developing children and adolescents." in: Molecular psychiatry, Vol. 16, Issue 9, pp. 917-26, 2011 (PubMed).

Park, Jeong, Lee et al.: "Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 41, pp. 17785-90, 2010 (PubMed).

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