Disrupted in Schizophrenia 1 (DISC1) (C-Term) antibody

Antigen: Disrupted in Schizophrenia 1 (DISC1)

Synonyms: SCZD9, C1orf136, FLJ13381, FLJ21640, FLJ25311, FLJ41105, KIAA0457, DISC1

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN658716

Additional Information

Alternative name: DISC1

Isotype: Ig

Description: Other names: Disrupted in schizophrenia 1 protein,DISC1,KIAA0457

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This DISC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 700-728 amino acids from the C-terminal region of human DISC1.

Comments:

Background: This gene encodes a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. The protein is involved in neurite outgrowth and cortical development through its interaction with other proteins. This gene is disrupted in a t(1,11)(q42.1,q14.3) translocation which segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].

Application Details

Concentration: 0.25 mg/ml

Purification: Purified

Research Area: Cell Signaling, Signaling, Chromatin, Neurology, Cell Structure

Restrictions: For Research Use only

Images

DISC1 Antibody (C-term) (ABIN658716) western blot analysis in Ramos cell line lysates (35ug/lane). This demonstrates the DISC1 antibody detected the DISC1 protein (arrow).

Publications

Product: Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).

Raznahan, Lee, Long et al.: "Common functional polymorphisms of DISC1 and cortical maturation in typically developing children and adolescents." in: Molecular psychiatry, Vol. 16, Issue 9, pp. 917-26, 2011 (PubMed).

Park, Jeong, Lee et al.: "Disrupted-in-schizophrenia 1 (DISC1) plays essential roles in mitochondria in collaboration with Mitofilin." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 41, pp. 17785-90, 2010 (PubMed).