Cleavage and Polyadenylation Specific Factor 3, 73kDa (CPSF3) (AA 192-221), (Center) antibody

Details for Product No. ABIN658724
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Antigen
Synonyms CPSF3, si:dkey-81b15.1, wu:fc32f10, zgc:101655, CPSF-73, CPSF73
Epitope
AA 192-221, Center
(9), (8), (6), (4), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(40), (7), (7), (4), (2), (2), (2), (1), (1)
Host
Rabbit
(28), (14)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(40), (20), (8), (5), (5), (4), (2), (2)
Pubmed 2 references available
Quantity 400 μL
Options
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Catalog No. ABIN658724
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Immunogen This CPSF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-221 AA from the Central region of human CPSF3.
Clone RB34115
Isotype Ig
Specificity This CPSF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-221 amino acids from the Central region of human CPSF3.
Predicted Reactivity Cow (Bovine),Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name CPSF3
Background Most eukaryotic mRNA precursors (pre-mRNAs) undergo extensive maturational processing, including cleavage and polyadenylation at the 3-prime end. CPSF3 encodes the 73-kD subunit of the cleavage and polyadenylation specificity factor (CPSF) and is the pre-mRNA 3-prime-end-processing endonuclease (Mandel et al., 2006 [PubMed 17128255]).
Synonyms: Cleavage and polyadenylation specificity factor subunit 3,CPSF3,CPSF73
Research Area Ubiquitin-related antibodies, Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Signaling, Chromatin, Metabolism, Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
anti-Cleavage and Polyadenylation Specific Factor 3, 73kDa (CPSF3) (AA 192-221), (Center) antibody CPSF3 Antibody (Center) (ABIN658724) western blot analysis in A375 cell line lysates (35 µg/lane). This demonstrates the CPSF3 antibody detected the CPSF3 protein (arrow).
Background publications Zhu, Yu, Shi et al.: "CSR1 induces cell death through inactivation of CPSF3." in: Oncogene, Vol. 28, Issue 1, pp. 41-51, 2009 (PubMed).

Rozenblatt-Rosen, Nagaike, Francis et al.: "The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 3, pp. 755-60, 2009 (PubMed).

Validation Images
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