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Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (C-Term), (AA 217-246) antibody

Details for Product No. ABIN658792
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Antigen
Epitope
C-Term, AA 217-246
(9), (8), (4), (3), (2), (2), (1), (1), (1), (1)
Reactivity
Human
(78), (56), (17)
Host
Rabbit
(53), (41), (21), (1), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(13), (13), (6), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Western Blotting (WB)
(69), (32), (28), (28), (13), (8), (5), (3), (2), (1), (1)
Pubmed 3 references available
Quantity 400 µL
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Catalog No. ABIN658792
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Immunogen This ICOSLG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-246 AA from the C-terminal region of human ICOSLG.
Clone RB35031
Isotype Ig
Specificity This ICOSLG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-246 amino acids from the C-terminal region of human ICOSLG.
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name ICOSLG
Background Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion, induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).
Synonyms: ICOS ligand,ICOSLG,B7H2, B7RP1, ICOSL, KIAA0653
Research Area Cell Signaling, Protein Modifications, Cell Structure, Cell Cycle
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
anti-Inducible T-Cell Co-Stimulator Ligand (ICOSLG) (C-Term), (AA 217-246) antibody ICOSLG Antibody (C-term) (ABIN658792) western blot analysis in HL-60 cell line lysates (35 µg/lane). This demonstrates the ICOSLG antibody detected the ICOSLG protein (arrow).
Background publications Dubois, Trynka, Franke et al.: "Multiple common variants for celiac disease influencing immune gene expression...." in: Nature genetics, Vol. 42, Issue 4, pp. 295-302, 2010 (PubMed).

Pan, Yang, Chen et al.: "Impact of female cigarette smoking on circulating B cells in vivo: the suppressed ICOSLG, TCF3, and VCAM1 gene functional network may inhibit normal cell function." in: Immunogenetics, Vol. 62, Issue 4, pp. 237-51, 2010 (PubMed).

Shimada, Miyagawa, Kawashima et al.: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." in: Human genetics, Vol. 128, Issue 4, pp. 433-41, 2010 (PubMed).

Validation Images
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