Origin Recognition Complex, Subunit 3 (ORC3) (N-Term) antibody

Antigen: Origin Recognition Complex, Subunit 3 (ORC3)

Synonyms: LAT, ORC3, LATHEO, DmORC3, ORC, l(2)49Fd, l(2)vr6, vr-6, vr6, DmelCG4088, CG4088, ORC3L, MGC128021, orc3, ATORC3, F5E19.30, F5E19_30, ORIGIN RECOGNITION COMPLEX SUBUNIT 3, LOC100226325

Binding Site: N-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN658794

Additional Information

Alternative name: ORC3L

Isotype: Ig

Description: Other names: Origin recognition complex subunit 3,ORC3L,LATHEO, ORC3

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This ORC3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of human ORC3L.

Comments:

Background: The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene.

Application Details

Concentration: 0.25 mg/ml

Purification: Purified

Research Area: Phospho-specific antibodies, Protein Modifications, Transcription Factors, Signaling, Chromatin, Cell Structure

Restrictions: For Research Use only

Images

ORC3L Antibody (N-term) (ABIN658794) western blot analysis in Hela cell line lysates (35ug/lane). This demonstrates the ORC3L antibody detected the ORC3L protein (arrow).

Publications

Product: Matsuoka, Ballif, Smogorzewska et al.: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, 2007 (PubMed).

Enjuanes, Benavente, Bosch et al.: "Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia." in: Cancer research, Vol. 68, Issue 24, pp. 10178-86, 2008 (PubMed).