Transcriptional Adaptor 2A (TADA2A) (Center) antibody

Antigen: Transcriptional Adaptor 2A (TADA2A)

Synonyms: ADA2, ADA2A, KL04P, hADA2, TADA2L, FLJ12705, MGC81519, TADA2A, MGC127042, tada2l, MGC154057, zgc:154057

Binding Site: Center

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN658832

Additional Information

Alternative name: TADA2L

Isotype: Ig

Description: Other names: Transcriptional adapter 2-alpha,TADA2A,TADA2L

Characteristics: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Specificity: This TADA2L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 201-230 amino acids from the Central region of human TADA2L.

Comments:

Background: Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined.

Application Details

Concentration: 0.25 mg/ml

Purification: Purified

Research Area: Transcription Factors, Signaling, Chromatin, Cell Structure

Restrictions: For Research Use only

Images

TADA2L Antibody (Center) (ABIN658832) western blot analysis in NCI-H292 cell line lysates (35ug/lane). This demonstrates the TADA2L antibody detected the TADA2L protein (arrow).

Publications

Product: Ruaño, Thompson, Kane et al.: "Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?" in: Pharmacogenomics, Vol. 11, Issue 7, pp. 959-71, 2010 (PubMed).