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Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) (C-Term), (AA 259-287) antibody

Details for Product No. ABIN658838
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Antigen
Synonyms
jnkk, mek4, mkk4, sek1, jnkk1, serk1, xmek2, mapkk4, prkmk4, 142758_at, CG9738, CT27508, D-MKK4, DMKK4, Dmel\\CG9738, JNKK2, MAPKK4, MKK4, Mpk4, SEK1/MKK4, dMKK4, dMkk4, hep, CT38386, DmelCG12798, Sek ... show more
jnkk, mek4, mkk4, sek1, jnkk1, serk1, xmek2, mapkk4, prkmk4, 142758_at, CG9738, CT27508, D-MKK4, DMKK4, Dmel\\CG9738, JNKK2, MAPKK4, MKK4, Mpk4, SEK1/MKK4, dMKK4, dMkk4, hep, CT38386, DmelCG12798, Sek1, 2, JNKK, Jnkk2, Mapkk7, Mek7, Mkk7, JNKK1, MEK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1, Serk1, ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 4, ATMEK4, ATMKK4, F19C24.26, F19C24_26, MAP KINASE KINASE 4, mitogen-activated protein kinase kinase 4, MKK4A-l, map2k4, zgc:136500 show less
Epitope
C-Term, AA 259-287
(55), (42), (41), (15), (12), (9), (7), (6), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Zebrafish (Danio rerio)
(265), (162), (153), (60), (52), (48), (36), (12), (2), (1), (1)
Host
Rabbit
(242), (25), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(9), (9), (9), (5), (5), (5), (5), (5), (5), (5), (5), (4), (4), (4)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(161), (104), (86), (50), (46), (36), (11), (9), (7), (5), (3), (1), (1)
Pubmed 2 references available
Quantity 400 µL
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Catalog No. ABIN658838
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Immunogen This Mouse Map2k4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 259-287 AA from the C-terminal region of mouse Map2k4.
Clone RB35403
Isotype Ig
Specificity This Mouse Map2k4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-287 amino acids from the C-terminal region of Mouse Map2k4.
Predicted Reactivity Xenopus laevis
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Map2k4
Background Dual specificity kinase that activates the JUN kinases MAPK8 (JNK1) and MAPK9 (JNK2) as well as MAPK14 (p38) but not MAPK1 (ERK2) or MAPK3 (ERK1).
Synonyms: Dual specificity mitogen-activated protein kinase kinase 4,Map2k4,Jnkk1, Prkmk4, Sek1, Serk1
Research Area Ubiquitin-related antibodies, Signaling, Phospho-specific antibodies, Cell Signaling, Protein Modifications, Chromatin, Cell Structure
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 0.48 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
anti-Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) (C-Term), (AA 259-287) antibody Mouse Map2k4 Antibody (C-term) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the Map2k4 antibody detected the Map2k4 protein (arrow).
anti-Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) (C-Term), (AA 259-287) antibody (2) Mouse Map2k4 Antibody (C-term) western blot analysis in Y79 cell line lysates (35ug/lane).This demonstrates the Map2k4 antibody detected the Map2k4 protein (arrow).
anti-Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) (C-Term), (AA 259-287) antibody (3) Mouse Map2k4 Antibody (C-term) western blot analysis in zebra fish brain tissue lysates (35ug/lane).This demonstrates the Mouse Map2k4 antibody detected the Mouse Map2k4 protein (arrow).
anti-Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4) (C-Term), (AA 259-287) antibody (4) Mouse Map2k4 Antibody (C-term) (AP14920b)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse cerebellum tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Map2k4 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Background publications Ahn, Kurie: "MKK4/SEK1 is negatively regulated through a feedback loop involving the E3 ubiquitin ligase itch." in: The Journal of biological chemistry, Vol. 284, Issue 43, pp. 29399-404, 2009 (PubMed).

Finegan, Tournier: "The mitogen-activated protein kinase kinase 4 has a pro-oncogenic role in skin cancer." in: Cancer research, Vol. 70, Issue 14, pp. 5797-806, 2010 (PubMed).

Validation Images
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