S100 Calcium Binding Protein B (S100B) (AA 28-56), (Center) antibody

Details for Product No. ABIN658853
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Antigen
Synonyms NEF, S100, S100-B, S100beta, AI850290, Bpb
Epitope
AA 28-56, Center
(13), (6), (3), (3), (2), (1), (1), (1)
Reactivity
Human
(130), (57), (52), (48), (25), (13), (4), (4), (1)
Host
Rabbit
(98), (61), (8), (4), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(12), (11), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Application
Western Blotting (WB)
(113), (80), (50), (48), (21), (20), (12), (11), (11), (7), (7), (3), (2), (2), (2), (1)
Pubmed 4 references available
Catalog no. ABIN658853
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This S100B/S-100 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-56 AA from the Central region of human S100B/S-100.
Clone RB35522
Isotype Ig
Specificity This S100B/S-100 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-56 amino acids from the Central region of human S100B/S-100.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus),Rabbit
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name S100B/S-100
Background The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21, however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
Synonyms: Protein S100-B,S100B,
Research Area Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Supplier Images
anti-S100 Calcium Binding Protein B (S100B) (AA 28-56), (Center) antibody S100B/S-100 Antibody (Center) (ABIN658853) western blot analysis in NCI-H460 cell line lysates (35 µg/lane). This demonstrates the S100B/S-100 antibody detected the S100B/S-100 protein (arrow).
Background publications Lin, Yang, Wilder et al.: "The calcium-binding protein S100B down-regulates p53 and apoptosis in malignant melanoma." in: The Journal of biological chemistry, Vol. 285, Issue 35, pp. 27487-98, 2010 (PubMed).

van Dieck, Lum, Teufel et al.: "S100 proteins interact with the N-terminal domain of MDM2." in: FEBS letters, Vol. 584, Issue 15, pp. 3269-74, 2010 (PubMed).

Egberts, Momkvist, Egberts et al.: "Serum S100B and LDH are not useful in predicting the sentinel node status in melanoma patients." in: Anticancer research, Vol. 30, Issue 5, pp. 1799-805, 2010 (PubMed).

Sahoo, Tröger, Heinemann et al.: "Current inhibition of human EAG1 potassium channels by the Ca2+ binding protein S100B." in: FEBS letters, Vol. 584, Issue 18, pp. 3896-900, 2010 (PubMed).

Hosts (98), (61), (8), (4), (2)
Reactivities (130), (57), (52), (48), (25), (13), (4), (4), (1)
Applications (113), (80), (50), (48), (21), (20), (12), (11), (11), (7), (7), (3), (2), (2), (2), (1)
Conjugates (12), (11), (4), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1)
Epitopes (13), (6), (3), (3), (2), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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