s100b antibody (S100 Calcium Binding Protein B) (AA 28-56)

Details for Product anti-S100B Antibody No. ABIN658853, Supplier: Log in to see
Antigen
  • AI266795
  • S100
  • S100a
  • NEF
  • S100-B
  • S100beta
  • S100P
  • AI850290
  • Bpb
  • S100 calcium binding protein A1
  • S100 calcium binding protein B
  • S100 protein, beta polypeptide, neural
  • S100a1
  • S100B
  • S100b
Alternatives
anti-Human s100b antibody for Cellular Assay
Epitope
AA 28-56, Center
41
15
13
12
10
9
8
6
3
2
2
1
1
1
1
1
1
Reactivity
Human
431
259
220
200
44
32
8
2
2
2
1
1
1
1
1
Host
Rabbit
280
180
8
5
3
Clonality (Clone)
Polyclonal ()
Conjugate
This s100b antibody is un-conjugated
33
27
16
13
11
11
10
10
10
10
10
10
10
10
9
9
6
4
4
4
3
3
2
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
351
226
210
194
183
174
130
25
13
13
9
8
7
4
4
2
2
1
1
Options
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Immunogen This S100B/S-100 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-56 AA from the Central region of human S100B/S-100.
Clone RB35522
Isotype Ig
Specificity This S100B/S-100 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-56 amino acids from the Central region of human S100B/S-100.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus),Rabbit
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name S100B/S-100 (S100B Antibody Abstract)
Background The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21, however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
Synonyms: Protein S100-B,S100B,
Research Area Cell Structure
Pathways Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades, Regulation of long-term Neuronal Synaptic Plasticity
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Western Blotting (WB) image for anti-s100b antibody (S100 Calcium Binding Protein B) (AA 28-56) (ABIN658853) S100B/S-100 Antibody (Center) (ABIN658853) western blot analysis in NCI-H460 cell lin...
Background publications Sahoo, Tröger, Heinemann, Schönherr: "Current inhibition of human EAG1 potassium channels by the Ca2+ binding protein S100B." in: FEBS letters, Vol. 584, Issue 18, pp. 3896-900, 2010 (PubMed).

Lin, Yang, Wilder, Carrier, Weber: "The calcium-binding protein S100B down-regulates p53 and apoptosis in malignant melanoma." in: The Journal of biological chemistry, Vol. 285, Issue 35, pp. 27487-98, 2010 (PubMed).

van Dieck, Lum, Teufel, Fersht: "S100 proteins interact with the N-terminal domain of MDM2." in: FEBS letters, Vol. 584, Issue 15, pp. 3269-74, 2010 (PubMed).

Egberts, Momkvist, Egberts, Kaehler, Hauschild: "Serum S100B and LDH are not useful in predicting the sentinel node status in melanoma patients." in: Anticancer research, Vol. 30, Issue 5, pp. 1799-805, 2010 (PubMed).