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Forkhead Box O4 (FOXO4) (Ser197) antibody

Antigen

Forkhead Box O4 (FOXO4)
Synonyms AFX, AFX1, MLLT7, MGC120490, afx, Afxh, Mllt7, MGC117660, RGD1561201, FOXO4, foxo4
Binding Site
Alternatives

Ser197
Clonality Monoclonal
Host
Alternatives

Mouse
Reactivity
Alternatives

Human, Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
5 references available
Certificates ISO 9001:2008
Catalog no. ABIN658929
Quantity 0.1 mg  (1mg/ml)
Price 464.29 $   Plus shipping costs $45.00
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Additional Information
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Alternative name AFX
Gene ID 4303
UniProt P98177
Isotype IgG
Description Other names: Fork head domain transcription factor AFX1, Forkhead box protein O4
Characteristics Purified Rabbit Polyclonal Antibody (Pab)
Specificity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Molecular Weight 53684 DA
Comments

Background: This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene.

Application Details
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Application Notes The suggested dilution is: WB: 1:500~1:1000 IHC: 1:50-1:100
Concentration 1mg/ml
Purification Purified
Buffer affinity Purified IgG, in PBS, 0.02% sodium azide and 50% glycerol.
Storage Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles
Research Area Ubiquitin-related antibodies, Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Cancer, Cell Cycle, Transcription Factors, Chromatin, Cell Structure
Restrictions For Research Use only

Publications
Application Details Alternatives back to top

Product Silhan, Vacha, Strnadova et al.: "14-3-3 protein masks the DNA binding interface of forkhead transcription factor FOXO4." in: The Journal of biological chemistry, Vol. 284, Issue 29, pp. 19349-60, 2009 (PubMed).

Zhou, Cao, Peng et al.: "FoxO4 inhibits NF-kappaB and protects mice against colonic injury and inflammation." in: Gastroenterology, Vol. 137, Issue 4, pp. 1403-14, 2009 (PubMed).

Ho, Wang, Whisenhunt et al.: "O-GlcNAcylation enhances FOXO4 transcriptional regulation in response to stress." in: FEBS letters, Vol. 584, Issue 1, pp. 49-54, 2009 (PubMed).

Zhu, Mounzih, Chehab et al.: "Effects of FoxO4 overexpression on cholesterol biosynthesis, triacylglycerol accumulation, and glucose uptake." in: Journal of lipid research, Vol. 51, Issue 6, pp. 1312-24, 2010 (PubMed).

Kwon, Wang, Thangaraju et al.: "PKG inhibits TCF signaling in colon cancer cells by blocking beta-catenin expression and activating FOXO4." in: Oncogene, Vol. 29, Issue 23, pp. 3423-34, 2010 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "Forkhead Box O4 (FOXO4)", type "Antibodies"
Hosts Rabbit (146), Goat (5), Mouse (1)
Reactivities Human (150), Mouse (Murine) (114), Rat (Rattus) (105), Cow (Bovine) (74), Dog (Canine) (74), Chicken (73), Horse (Equine) (72), Pig (Porcine) (36), Hamster (2), Cat (Feline) (1)
Applications Western Blotting (WB) (87), Immunofluorescence (IF) (74), ELISA (45), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (29), Immunohistochemistry (IHC) (19), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (12), Immunocytochemistry (ICC) (11), Immunoprecipitation (IP) (7), Immunoelectron Microscopy (IEM) (4), Flow Cytometry (FACS) (1)
Conjugates Alexa Fluor 350 (4), Alexa Fluor 488 (4), Alexa Fluor 555 (4), Alexa Fluor 647 (4), Biotin (4), Cy3 (4), Cy5 (4), Cy5.5 (4), Cy7 (4), FITC (4), Gold (4), HRP (4), PE (4), PE,Cy3 (4), PE,Cy5 (4), PE,Cy5.5 (4), PE,Cy7 (4)
Epitopes pSer197 (32), pSer193 (21), pSer262 (20), N-Term (9), C-Term (6), Internal Region (5), Ser197 (3), AA 59-73 (1), Phosphospecific (1), pThr32 (1), pThr451 (1), phospho (1)