|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Forkhead Box O4 (FOXO4) (Ser197) antibody
|Synonyms||AFX, AFX1, MLLT7, MGC120490, afx, Afxh, Mllt7, MGC117660, RGD1561201, FOXO4, foxo4|
Human, Rat (Rattus)
Alternatives Western Blotting (WB), Immunohistochemistry (IHC)
|5 references available|
|Quantity||0.1 mg (1mg/ml)|
|Price||464.29 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Description||Other names: Fork head domain transcription factor AFX1, Forkhead box protein O4|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.|
|Molecular Weight||53684 DA|
Background: This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene.
|Application Notes||The suggested dilution is: WB: 1:500~1:1000 IHC: 1:50-1:100|
|Buffer||affinity Purified IgG, in PBS, 0.02% sodium azide and 50% glycerol.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Ubiquitin-related antibodies, Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Cancer, Cell Cycle, Transcription Factors, Chromatin, Cell Structure|
|Restrictions||For Research Use only|
Silhan, Vacha, Strnadova et al.: "14-3-3 protein masks the DNA binding interface of forkhead transcription factor FOXO4." in: The Journal of biological chemistry, Vol. 284, Issue 29, pp. 19349-60, 2009 (PubMed).
Zhou, Cao, Peng et al.: "FoxO4 inhibits NF-kappaB and protects mice against colonic injury and inflammation." in: Gastroenterology, Vol. 137, Issue 4, pp. 1403-14, 2009 (PubMed).
Ho, Wang, Whisenhunt et al.: "O-GlcNAcylation enhances FOXO4 transcriptional regulation in response to stress." in: FEBS letters, Vol. 584, Issue 1, pp. 49-54, 2009 (PubMed).
Zhu, Mounzih, Chehab et al.: "Effects of FoxO4 overexpression on cholesterol biosynthesis, triacylglycerol accumulation, and glucose uptake." in: Journal of lipid research, Vol. 51, Issue 6, pp. 1312-24, 2010 (PubMed).
Kwon, Wang, Thangaraju et al.: "PKG inhibits TCF signaling in colon cancer cells by blocking beta-catenin expression and activating FOXO4." in: Oncogene, Vol. 29, Issue 23, pp. 3423-34, 2010 (PubMed).