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Forkhead Box O4 (FOXO4) (pSer197) antibody

Details for Product No. ABIN658930
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Antigen
Synonyms FOXO4, foxo4, AFX, AFX1, MLLT7, Afxh, Mllt7, afx, RGD1561201
Epitope
pSer197
(39), (26), (22), (18), (17), (7), (5), (5), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(204), (151), (106), (61), (48), (48), (36), (2), (1)
Host
Mouse
(199), (5), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(6), (6), (6), (5), (5), (5), (5), (5), (5), (5), (5), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(147), (72), (50), (47), (39), (27), (23)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN658930
464.29 $
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Isotype IgG
Specificity The antibody was affinity-purified from rabbit antiserum using epitope-specific phosphopeptide column, and the antibody against non-phosphopeptide was removed using non-phosphopeptide column corresponding to the phosphorylation site.
Purification Affinity purified
Alternative Name AFX
Background This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms: Fork head domain transcription factor AFX1, Forkhead box protein O4
Molecular Weight 53684 DA
Gene ID 4303
UniProt P98177
Research Area Ubiquitin-related antibodies, Translation Factors, Signaling, Phospho-specific antibodies, Protein Modifications, Cancer, Cell Cycle, Transcription Factors, Chromatin, Cell Structure
Application Notes The suggested dilution is: WB: 1:500-1000 ,IHC: 1:50-1:100 ,IF: 1:100-200
Comment

Background: This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene.

Restrictions For Research Use only
Format Liquid
Concentration 1mg/ml
Buffer PBS, 0.02% sodium azide and 50% glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Silhan, Vacha, Strnadova et al.: "14-3-3 protein masks the DNA binding interface of forkhead transcription factor FOXO4." in: The Journal of biological chemistry, Vol. 284, Issue 29, pp. 19349-60, 2009 (PubMed).

Zhou, Cao, Peng et al.: "FoxO4 inhibits NF-kappaB and protects mice against colonic injury and inflammation." in: Gastroenterology, Vol. 137, Issue 4, pp. 1403-14, 2009 (PubMed).

Ho, Wang, Whisenhunt et al.: "O-GlcNAcylation enhances FOXO4 transcriptional regulation in response to stress." in: FEBS letters, Vol. 584, Issue 1, pp. 49-54, 2009 (PubMed).

Zhu, Mounzih, Chehab et al.: "Effects of FoxO4 overexpression on cholesterol biosynthesis, triacylglycerol accumulation, and glucose uptake." in: Journal of lipid research, Vol. 51, Issue 6, pp. 1312-24, 2010 (PubMed).

Kwon, Wang, Thangaraju et al.: "PKG inhibits TCF signaling in colon cancer cells by blocking beta-catenin expression and activating FOXO4." in: Oncogene, Vol. 29, Issue 23, pp. 3423-34, 2010 (PubMed).

Validation Images
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