APP antibody (Amyloid beta (A4) Precursor Protein) (Thr668)

Details for Product anti-APP Antibody No. ABIN658931, Supplier: Log in to see
Antigen
  • APP
  • APP-like
  • APPL
  • Abeta
  • BcDNA:GH04413
  • CG7727
  • Dmel\\CG7727
  • EG:65F1.5
  • appl
  • aaa
  • abeta
  • abpp
  • ad1
  • appi
  • ctfgamma
  • cvap
  • pn2
  • AAA
  • ABETA
  • ABPP
  • AD1
  • APPI
  • CTFgamma
  • CVAP
  • PN-II
  • PN2
  • Abpp
  • Adap
  • Ag
  • Cvap
  • E030013M08Rik
  • betaApp
  • app
  • wu:fj34d10
  • wu:fk65e12
  • zgc:85740
  • beta amyloid protein precursor-like
  • amyloid beta (A4) precursor protein
  • amyloid beta (A4) precursor protein a
  • beta amyloid protein precursor
  • Appl
  • APP
  • app
  • App
  • appa
  • LOC100009546
Alternatives
anti-Human APP antibody for Immunofluorescence (fixed cells)
Epitope
Thr668
101
95
67
37
30
24
23
19
16
16
15
15
14
14
12
10
7
7
7
6
6
6
6
5
5
5
5
5
5
5
5
5
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Rat (Rattus)
820
365
351
40
27
21
19
18
15
13
12
10
7
7
4
4
4
3
2
2
1
Host
Mouse
580
224
45
6
2
Clonality
Monoclonal
Conjugate
This APP antibody is un-conjugated
47
37
37
14
13
13
13
12
12
12
12
12
12
12
11
8
8
3
3
2
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
574
318
233
149
148
100
47
38
35
18
14
10
9
8
6
3
2
2
1
1
1
1
Options
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Isotype IgG
Specificity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purification Affinity purified
Alternative Name APP (APP Antibody Abstract)
Background This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Synonyms: C31, Amyloid intracellular domain 50, AICD-50, AID(50), Gamma-CTF(50), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 57, AICD-57, AID(57), Gamma-CTF(57), Gamma-secretase C-terminal fragment 57, Amyloid intracellular domain 59, AICD-
Molecular Weight 86943 DA
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Neurology
Pathways Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour
Application Notes The suggested dilution is: WB: 1:500-1:1000
Comment

Background: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Restrictions For Research Use only
Format Liquid
Concentration 1mg/ml
Buffer PBS, 0.02% sodium azide and 50% glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Ando, Oishi, Takeda, Iijima, Isohara, Nairn, Kirino, Greengard, Suzuki: "Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 11, pp. 4421-7, 1999 (PubMed).

Hung, Selkoe: "Selective ectodomain phosphorylation and regulated cleavage of beta-amyloid precursor protein." in: The EMBO journal, Vol. 13, Issue 3, pp. 534-42, 1994 (PubMed).

Suzuki, Oishi, Marshak, Czernik, Nairn, Greengard: "Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein." in: The EMBO journal, Vol. 13, Issue 5, pp. 1114-22, 1994 (PubMed).