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Amyloid beta (A4) Precursor Protein (APP) (pThr668) antibody

Antigen

Amyloid beta (A4) Precursor Protein (APP)
Synonyms APP, APP-like, APPL, Abeta, BcDNA:GH04413, EG:65F1.5, DmelCG7727, CG7727, AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, CTFgamma, aaa, ad1, pn2, abpp, appi, cvap, abeta, MGC88882, ctfgamma
Binding Site
Alternatives

pThr668
Clonality Monoclonal
Host
Alternatives

Mouse
Reactivity
Alternatives

Human, Rat (Rattus)
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB)
3 references available
Certificates ISO 9001:2008
Catalog no. ABIN658932
Quantity 0.1 mg  (1mg/ml)
Price 464.29 $   Plus shipping costs $45.00
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Additional Information
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Alternative name APP
Isotype IgG
Description Other names: C31, Amyloid intracellular domain 50, AICD-50, AID(50), Gamma-CTF(50), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 57, AICD-57, AID(57), Gamma-CTF(57), Gamma-secretase C-terminal fragment 57, Amyloid intracellular domain 59, AICD-
Characteristics Purified Rabbit Polyclonal Antibody (Pab)
Specificity The antibody was affinity-purified from rabbit antiserum using epitope-specific phosphopeptide column, and the antibody against non-phosphopeptide was removed using non-phosphopeptide column corresponding to the phosphorylation site.
Molecular Weight 86943 DA
Comments

Background: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Application Details
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Application Notes The suggested dilution is: WB: 1:500~1:1000
Concentration 1mg/ml
Purification Purified
Buffer affinity Purified IgG, in PBS, 0.02% sodium azide and 50% glycerol.
Storage Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Neurology
Restrictions For Research Use only

Publications
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Product Suzuki, Oishi, Marshak et al.: "Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein." in: The EMBO journal, Vol. 13, Issue 5, pp. 1114-22, 1994 (PubMed).

Hung, Selkoe: "Selective ectodomain phosphorylation and regulated cleavage of beta-amyloid precursor protein." in: The EMBO journal, Vol. 13, Issue 3, pp. 534-42, 1994 (PubMed).

Ando, Oishi, Takeda et al.: "Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 11, pp. 4421-7, 1999 (PubMed).

Alternatives
Application Details Publications back to top

Alternatives for antigen "Amyloid beta (A4) Precursor Protein (APP)", type "Antibodies"
Hosts Rabbit (315), Mouse (67), Goat (34), Chicken (3)
Reactivities Human (383), Mouse (Murine) (224), Rat (Rattus) (211), Cow (Bovine) (152), Chicken (134), Dog (Canine) (134), Pig (Porcine) (132), Horse (Equine) (108), Sheep (Ovine) (18), Monkey (7), Rabbit (3), Guinea Pig (2), Xenopus laevis (2), Zebrafish (2), Cat (Feline) (1), Fruit Fly (Drosophila melanogaster) (1), Primate (1)
Applications Western Blotting (WB) (260), Immunofluorescence (IF) (146), ELISA (142), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (94), Immunohistochemistry (IHC) (64), Immunoprecipitation (IP) (29), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (26), Flow Cytometry (FACS) (12), Immunoelectron Microscopy (IEM) (8), Immunohistochemistry (Fixed) (IHC (fx)) (8), Immunohistochemistry (Frozen Sections) (IHC (fro)) (7), Immunocytochemistry (ICC) (5), Dot Blot (Dot) (1), Enzyme Immunoassay (EIA) (1)
Conjugates Biotin (10), FITC (10), HRP (9), Alexa Fluor 350 (8), Alexa Fluor 488 (8), Alexa Fluor 555 (8), Alexa Fluor 647 (8), Cy3 (8), Cy5 (8), Cy5.5 (8), Cy7 (8), Gold (8), PE (8), PE,Cy3 (8), PE,Cy5 (8), PE,Cy5.5 (8), PE,Cy7 (8)
Epitopes Middle Region (36), pThr743 (36), N-Term (32), C-Term (26), pThr668 (26), pSer198 (21), pSer730 (21), pTyr757 (19), Transcript Variant 1 (10), AA 44-63 (4), AA 737-751 (4), AA 292-312 (3), Internal Region (3), Thr668 (3), pTyr756 (3), AA 18-289 (2), AA 653-662 (2), AA 660-669 (2), AA 681-695 (2), AA 747-761 (2), Frameshift Mutant (2), AA 1-14 (1), AA 1-16 (1), AA 18-38 (1), AA 339-348 (1), AA 350-450 (1), AA 36-42 (1), AA 671-685 (1), AA 73-7 (1), C-Term,Asp672 (1), Center (1), Extracellular Domain (1), Frameshift Mutant, AA 339-348 (1), Frameshift Mutant, C-Term (1), KPI Domain (1), N-Term,AA 18-32 (1), OX-2 Domain (1), Precursor, AA 653-662 (1), Precursor, C-Term, AA 737-751 (1), Ser730 (1), Thr743, Thr668 (1), Tyr756 (1), Wild Type (1), pThr743, pThr668 (1), pThr743,pThr668 (1)