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Details for Product No. ABIN658932

Amyloid beta (A4) Precursor Protein (APP) (pThr668) antibody

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Antigen
Synonyms
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, APP, APP-like, APPL, Abeta, BcDNA:GH04413, CG7727, Dmel\\CG7727, EG:65F1.5, appl, Abpp, Adap, Ag, Cvap, E030013M08Rik, betaApp, app, wu:fj34d10 ... show more
Epitope
»Alternatives pThr668
Reactivity
»Alternatives Human, Rat (Rattus)
Host
»Alternatives Mouse
Clonality Monoclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 3 references available
Catalog no. ABIN658932
Quantity 0.1 mg
Price
464.29 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Isotype IgG
Specificity The antibody was affinity-purified from rabbit antiserum using epitope-specific phosphopeptide column, and the antibody against non-phosphopeptide was removed using non-phosphopeptide column corresponding to the phosphorylation site.
Purification Affinity purified
Alternative Name APP
Background This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Synonyms: C31, Amyloid intracellular domain 50, AICD-50, AID(50), Gamma-CTF(50), Gamma-secretase C-terminal fragment 50, Amyloid intracellular domain 57, AICD-57, AID(57), Gamma-CTF(57), Gamma-secretase C-terminal fragment 57, Amyloid intracellular domain 59, AICD-
Molecular Weight 86943 DA
Research Area Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Neurology
Application Notes The suggested dilution is: WB: 1:500~1:1000
Comment

Background: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

Restrictions For Research Use only
Format Liquid
Concentration 1mg/ml
Buffer PBS, 0.02% sodium azide and 50% glycerol.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Suzuki, Oishi, Marshak et al.: "Cell cycle-dependent regulation of the phosphorylation and metabolism of the Alzheimer amyloid precursor protein." in: The EMBO journal, Vol. 13, Issue 5, pp. 1114-22, 1994 (PubMed).

Hung, Selkoe: "Selective ectodomain phosphorylation and regulated cleavage of beta-amyloid precursor protein." in: The EMBO journal, Vol. 13, Issue 3, pp. 534-42, 1994 (PubMed).

Ando, Oishi, Takeda et al.: "Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 11, pp. 4421-7, 1999 (PubMed).

Alternatives for antigen "Amyloid beta (A4) Precursor Protein (APP)", type "Antibodies"
Hosts (381), (109), (42), (5), (1)
Reactivities (489), (231), (226), (106), (98), (95), (92), (17), (14), (7), (5), (5), (4), (4), (3), (3), (3), (3), (2), (2), (1), (1), (1)
Applications (374), (206), (130), (98), (90), (37), (36), (15), (14), (11), (7), (7), (4), (2), (2), (1), (1), (1), (1)
Conjugates (14), (11), (10), (9), (9), (9), (9), (9), (9), (9), (9), (1), (1)
Epitopes (66), (52), (30), (29), (19), (13), (13), (10), (9), (7), (6), (6), (5), (5), (5), (4), (4), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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