Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL) (Tyr770) antibody

Details for Product No. ABIN658935
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms 4732447J05Rik, Cbl-2, c-Cbl, cbl, C-CBL, CBL2, FRA11B, NSLL, RNF55, c-cbl-like, RGD1561386
Epitope
Tyr770
(30), (30), (22), (21), (19), (5), (4), (4), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(223), (139), (136), (62), (50), (50), (24)
Host
Mouse
(200), (19), (8), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6)
Application
Immunohistochemistry (IHC)
(158), (70), (69), (60), (55), (41), (18), (18), (15), (9), (4), (3), (2), (2), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN658935
464.29 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Isotype IgG
Specificity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purification Affinity purified
Alternative Name C-Cbl
Background The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.
Synonyms: RING finger protein 55, Casitas B-lineage lymphoma proto-oncogene, Proto-oncogene c-Cbl, Signal transduction protein CBL, E3 ubiquitin-protein ligase CBL
Molecular Weight 99633 DA
Gene ID 867
UniProt P22681
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Cancer, Cell Structure
Application Notes The suggested dilution is: IHC: 1:50-1:100
Comment

Background: The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.

Restrictions For Research Use only
Format Liquid
Concentration 1mg/ml
Buffer PBS, 0.02% sodium azide and 50% glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Ye, Cihil, Stolz et al.: "c-Cbl facilitates endocytosis and lysosomal degradation of cystic fibrosis transmembrane conductance regulator in human airway epithelial cells." in: The Journal of biological chemistry, Vol. 285, Issue 35, pp. 27008-18, 2010 (PubMed).

Matsuda, Taira, Sakashita et al.: "Long-term survival after nonintensive chemotherapy in some juvenile myelomonocytic leukemia patients with CBL mutations, and the possible presence of healthy persons with the mutations." in: Blood, Vol. 115, Issue 26, pp. 5429-31, 2010 (PubMed).

Martinelli, De Luca, Stellacci et al.: "Heterozygous germline mutations in the CBL tumor-suppressor gene cause a Noonan syndrome-like phenotype. ..." in: American journal of human genetics, Vol. 87, Issue 2, pp. 250-7, 2010 (PubMed).

Rocquain, Carbuccia, Trouplin et al.: "Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias." in: BMC cancer, Vol. 10, pp. 401, 2010 (PubMed).

Niemeyer, Kang, Shin et al.: "Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia." in: Nature genetics, Vol. 42, Issue 9, pp. 794-800, 2010 (PubMed).

Validation Images
Did you look for something else?
back to top