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CBL antibody (Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence) (Tyr770)

Details for Product anti-CBL Antibody No. ABIN658935, Supplier: Log in to see
Antigen
  • 4732447J05Rik
  • Cbl-2
  • c-Cbl
  • cbl
  • C-CBL
  • CBL2
  • FRA11B
  • NSLL
  • RNF55
  • c-cbl-like
  • RGD1561386
Alternatives
anti-Human CBL antibody for Western Blotting
Epitope
Tyr770
38
33
26
23
17
5
5
4
4
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
227
133
127
6
4
4
4
1
1
1
Host
Mouse
190
32
9
1
Clonality
Monoclonal
Conjugate
This CBL antibody is un-conjugated
7
6
6
5
5
5
5
5
5
5
5
5
2
Application
Immunohistochemistry (IHC)
150
63
59
56
49
30
18
13
5
5
4
3
3
1
1
1
1
1
Supplier
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Isotype IgG
Specificity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purification Affinity purified
Alternative Name C-Cbl (CBL Antibody Abstract)
Background The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.
Synonyms: RING finger protein 55, Casitas B-lineage lymphoma proto-oncogene, Proto-oncogene c-Cbl, Signal transduction protein CBL, E3 ubiquitin-protein ligase CBL
Molecular Weight 99633 DA
Gene ID 867
UniProt P22681
Research Area Signaling, Phospho-specific antibodies, Protein Modifications, Cancer, Cell Structure
Pathways TCR Signaling, Interferon-gamma Pathway, EGFR Signaling Pathway
Application Notes The suggested dilution is: IHC: 1:50-1:100
Comment

Background: The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.

Restrictions For Research Use only
Format Liquid
Concentration 1mg/ml
Buffer PBS, 0.02% sodium azide and 50% glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Niemeyer, Kang, Shin et al.: "Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia. ..." in: Nature genetics, Vol. 42, Issue 9, pp. 794-800, 2010 (PubMed).

Rocquain, Carbuccia, Trouplin et al.: "Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias." in: BMC cancer, Vol. 10, pp. 401, 2010 (PubMed).

Martinelli, De Luca, Stellacci et al.: "Heterozygous germline mutations in the CBL tumor-suppressor gene cause a Noonan syndrome-like phenotype. ..." in: American journal of human genetics, Vol. 87, Issue 2, pp. 250-7, 2010 (PubMed).

Matsuda, Taira, Sakashita et al.: "Long-term survival after nonintensive chemotherapy in some juvenile myelomonocytic leukemia patients with CBL mutations, and the possible presence of healthy persons with the mutations." in: Blood, Vol. 115, Issue 26, pp. 5429-31, 2010 (PubMed).

Ye, Cihil, Stolz et al.: "c-Cbl facilitates endocytosis and lysosomal degradation of cystic fibrosis transmembrane conductance regulator in human airway epithelial cells." in: The Journal of biological chemistry, Vol. 285, Issue 35, pp. 27008-18, 2010 (PubMed).