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CREB1 antibody (CAMP Responsive Element Binding Protein 1) (Ser133)

Details for Product anti-CREB1 Antibody No. ABIN658944, Supplier: Log in to see
Antigen
  • creb
  • CREB1
  • Creb1
  • CREB
  • 2310001E10Rik
  • 3526402H21Rik
  • AV083133
  • Creb
  • Creb-1
  • creb1
  • zgc:55598
  • cAMP responsive element binding protein 1
  • cAMP responsive element binding protein 1a
  • cyclic AMP response element binding protein
  • CREB1
  • creb1
  • Creb1
  • LOC100351999
  • creb1a
  • CREB
Alternatives
anti-Human CREB1 antibody for Western Blotting
Epitope
Ser133
113
38
36
35
20
18
16
16
15
15
8
7
7
6
5
5
5
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Rat (Rattus)
508
327
293
41
41
36
29
27
25
24
21
14
13
10
7
7
3
1
1
1
1
1
1
Host
Mouse
425
83
11
1
Clonality
Monoclonal
Conjugate
This CREB1 antibody is un-conjugated
17
14
14
7
6
6
6
5
3
3
3
3
3
3
3
3
3
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
405
211
181
83
83
44
42
30
29
11
11
10
4
3
3
2
1
1
1
1
Options
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Isotype IgG
Specificity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purification Affinity purified
Alternative Name Creb (CREB1 Antibody Abstract)
Background This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
Synonyms: Cyclic AMP-responsive element-binding protein 1, cAMP-responsive element-binding protein 1, CREB-1
Molecular Weight 36688 DA
Gene ID 1385
UniProt P16220
Research Area Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Signaling, Cell Structure
Pathways TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Cell Size, Toll-Like Receptors Cascades
Application Notes IHC: 1:50-1:100, WB: 1:500-1:1000
Comment

Background: This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.

Restrictions For Research Use only
Format Liquid
Concentration 1mg/ml
Buffer PBS, 0.02% sodium azide and 50% glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Jablonski, McAteer, de Bakker, Franks, Pollin, Hanson, Saxena, Fowler, Shuldiner, Knowler, Altshuler, Florez: "Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program." in: Diabetes, Vol. 59, Issue 10, pp. 2672-81, 2010 (PubMed).

Serretti, Chiesa, Calati, Massat, Linotte, Kasper, Lecrubier, Antonijevic, Forray, Snyder, Bollen, Zohar, De Ronchi, Souery, Mendlewicz: "A preliminary investigation of the influence of CREB1 gene on treatment resistance in major depression." in: Journal of affective disorders, Vol. 128, Issue 1-2, pp. 56-63, 2010 (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Son, Lee, Kim, Ha, Lee: "cAMP-response-element-binding protein positively regulates breast cancer metastasis and subsequent bone destruction." in: Biochemical and biophysical research communications, Vol. 398, Issue 2, pp. 309-14, 2010 (PubMed).

Wang, Iwasaki, Ficara, Lin, Matheny, Wong, Smith, Cleary: "GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis." in: Cancer cell, Vol. 17, Issue 6, pp. 597-608, 2010 (PubMed).