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CREB1 antibody (CAMP Responsive Element Binding Protein 1) (Ser133)

Details for Product anti-CREB1 Antibody No. ABIN658944, Supplier: Log in to see
Antigen
  • creb
  • CREB1
  • Creb1
  • CREB
  • 2310001E10Rik
  • 3526402H21Rik
  • AV083133
  • Creb
  • Creb-1
  • creb1
  • zgc:55598
Alternatives
anti-Human CREB1 antibody for Western Blotting
Epitope
Ser133
110
35
33
28
23
20
17
16
16
13
10
7
7
5
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Rat (Rattus)
470
232
225
26
24
18
17
14
14
9
9
9
2
2
1
1
Host
Mouse
406
70
10
1
Clonality
Monoclonal
Conjugate
This CREB1 antibody is un-conjugated
15
14
13
7
6
6
6
5
4
3
3
3
3
3
3
Application
Immunohistochemistry (IHC), Western Blotting (WB)
370
214
184
66
58
39
35
28
26
11
8
3
3
2
2
1
1
1
Supplier
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Isotype IgG
Specificity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purification Affinity purified
Alternative Name Creb (CREB1 Antibody Abstract)
Background This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
Synonyms: Cyclic AMP-responsive element-binding protein 1, cAMP-responsive element-binding protein 1, CREB-1
Molecular Weight 36688 DA
Gene ID 1385
UniProt P16220
Research Area Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Signaling, Cell Structure
Pathways TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes IHC: 1:50-1:100, WB: 1:500-1:1000
Comment

Background: This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.

Restrictions For Research Use only
Format Liquid
Concentration 1mg/ml
Buffer PBS, 0.02% sodium azide and 50% glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Jablonski, McAteer, de Bakker et al.: "Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program." in: Diabetes, Vol. 59, Issue 10, pp. 2672-81, 2010 (PubMed).

Serretti, Chiesa, Calati et al.: "A preliminary investigation of the influence of CREB1 gene on treatment resistance in major depression." in: Journal of affective disorders, Vol. 128, Issue 1-2, pp. 56-63, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Son, Lee, Kim et al.: "cAMP-response-element-binding protein positively regulates breast cancer metastasis and subsequent bone destruction." in: Biochemical and biophysical research communications, Vol. 398, Issue 2, pp. 309-14, 2010 (PubMed).

Wang, Iwasaki, Ficara et al.: "GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis." in: Cancer cell, Vol. 17, Issue 6, pp. 597-608, 2010 (PubMed).