CAMP Responsive Element Binding Protein 1 (CREB1) (Ser133) antibody

Details for Product No. ABIN658944
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Antigen
Synonyms CREB, Creb, Creb-1, AV083133, 2310001E10Rik, 3526402H21Rik, creb, creb1, zgc:55598, CREB1, Creb1
Epitope
Ser133
(76), (35), (26), (18), (14), (13), (8), (7), (5), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(334), (238), (225), (75), (69), (68), (45), (9), (6), (6), (5), (1), (1), (1)
Host
Mouse
(297), (53), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(8), (7), (6), (6), (6), (6), (6), (6), (6), (6), (6)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(257), (138), (130), (74), (60), (39), (29), (21), (7), (4), (2), (2), (1), (1), (1), (1)
Pubmed 5 references available
Catalog no. ABIN658944
Quantity 0.1 mg
Price
464.29 $   Plus shipping costs $45.00
Options
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Isotype IgG
Specificity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purification Affinity purified
Alternative Name Creb
Background This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.
Synonyms: Cyclic AMP-responsive element-binding protein 1, cAMP-responsive element-binding protein 1, CREB-1
Molecular Weight 36688 DA
Gene ID 1385
UniProt P16220
Research Area Translation Factors, Phospho-specific antibodies, Protein Modifications, Transcription Factors, Chromatin, Signaling, Cell Structure
Application Notes IHC: 1:50-1:100, WB: 1:500-1:1000
Comment

Background: This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.

Restrictions For Research Use only
Format Liquid
Concentration 1mg/ml
Buffer PBS, 0.02% sodium azide and 50% glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Wang, Iwasaki, Ficara et al.: "GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis." in: Cancer cell, Vol. 17, Issue 6, pp. 597-608, 2010 (PubMed).

Son, Lee, Kim et al.: "cAMP-response-element-binding protein positively regulates breast cancer metastasis and subsequent bone destruction." in: Biochemical and biophysical research communications, Vol. 398, Issue 2, pp. 309-14, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Serretti, Chiesa, Calati et al.: "A preliminary investigation of the influence of CREB1 gene on treatment resistance in major depression." in: Journal of affective disorders, Vol. 128, Issue 1-2, pp. 56-63, 2010 (PubMed).

Jablonski, McAteer, de Bakker et al.: "Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program." in: Diabetes, Vol. 59, Issue 10, pp. 2672-81, 2010 (PubMed).

Hosts (297), (53), (1)
Reactivities (334), (238), (225), (75), (69), (68), (45), (9), (6), (6), (5), (1), (1), (1)
Applications (257), (138), (130), (74), (60), (39), (29), (21), (7), (4), (2), (2), (1), (1), (1), (1)
Conjugates (8), (7), (6), (6), (6), (6), (6), (6), (6), (6), (6)
Epitopes (76), (35), (26), (18), (14), (13), (8), (7), (5), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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