V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) (ERBB3) (Tyr1328) antibody

Details for Product No. ABIN658959
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Antigen
Synonyms C76256, Erbb-3, Erbb3r, Her3, nuc-ErbB3, ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3, ERBB3
Epitope
Tyr1328
(27), (25), (19), (19), (18), (12), (10), (6), (6), (4), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Rat (Rattus)
(295), (154), (134), (69), (44), (39), (24), (17), (1)
Host
Mouse
(211), (98), (11), (1), (1)
Clonality
Monoclonal
Conjugate
Un-conjugated
(14), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
(180), (120), (80), (70), (64), (59), (51), (41), (22), (5), (4), (3), (2)
Pubmed 5 references available
Catalog no. ABIN658959
Quantity 0.1 mg
Price
464.29 $   Plus shipping costs $45.00
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Isotype IgG
Specificity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purification Affinity purified
Alternative Name HER3 (ErbB3)
Background This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
Synonyms: Tyrosine kinase-type cell surface receptor HER3, Proto-oncogene-like protein c-ErbB-3, Receptor tyrosine-protein kinase erbB-3
Molecular Weight 148098 DA
Gene ID 2065
UniProt P21860
Research Area Ubiquitin-related antibodies, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Chromatin, Signaling
Application Notes The suggested dilution is: WB: 1:500-1:1000 ,IHC: 1:50-1:100
Comment

Background: This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

Restrictions For Research Use only
Format Liquid
Concentration 1mg/ml
Buffer PBS, 0.02% sodium azide and 50% glycerol.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Nikitin, Lavrikova, Seregin et al.: "[Association of the polymorphisms of the ERBB3 and SH2B3 genes with type 1 diabetes]." in: Molekuliarnaia biologiia, Vol. 44, Issue 2, pp. 257-62, 2010 (PubMed).

Chen, Siddiqui, Bose et al.: "Nrdp1-mediated regulation of ErbB3 expression by the androgen receptor in androgen-dependent but not castrate-resistant prostate cancer cells." in: Cancer research, Vol. 70, Issue 14, pp. 5994-6003, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Johnatty, Beesley, Chen et al.: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).

Hinks, Martin, Flynn et al.: "Investigation of type 1 diabetes and coeliac disease susceptibility loci for association with juvenile idiopathic arthritis." in: Annals of the rheumatic diseases, Vol. 69, Issue 12, pp. 2169-72, 2010 (PubMed).

Hosts (211), (98), (11), (1), (1)
Reactivities (295), (154), (134), (69), (44), (39), (24), (17), (1)
Applications (180), (120), (80), (70), (64), (59), (51), (41), (22), (5), (4), (3), (2)
Conjugates (14), (7), (7), (7), (7), (7), (7), (7), (7), (7), (7), (1), (1), (1), (1), (1)
Epitopes (27), (25), (19), (19), (18), (12), (10), (6), (6), (4), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
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