anti-Integrin beta 3 antibody (ITGB3) (Tyr785)

Details for Product anti-ITGB3 Antibody No. ABIN658966
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Antigen
Synonyms CD61, GP3A, INGRB3, BDPLT16, BDPLT2, GPIIIa, GT, INTB3, integrin, GPIIIA
Epitope
Tyr785
(41), (37), (27), (18), (14), (11), (5), (4), (4), (4), (4), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(445), (211), (113), (14), (9), (8), (8), (5), (4), (4), (4), (4), (4), (2), (2), (2), (1), (1), (1), (1)
Host
Mouse
(249), (223), (98), (2), (2)
Clonality
Monoclonal
Conjugate
This Integrin beta 3 antibody is un-conjugated
(87), (59), (36), (8), (7), (6), (4), (3), (3), (3), (3), (3), (3), (3), (1)
Application
Western Blotting (WB)
(316), (250), (118), (75), (75), (67), (63), (30), (15), (14), (10), (10), (10), (7), (6), (5), (4), (3)
Pubmed 5 references available
Quantity 0.1 mg
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Isotype IgG
Specificity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purification Affinity purified
Alternative Name Integrin Beta-3 (ITGB3 Antibody Abstract)
Background The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
Synonyms: CD_antigen=CD61, Flags: Precursor, Platelet membrane glycoprotein IIIa, GPIIIa, Integrin beta-3
Molecular Weight 87058 DA
Gene ID 3690
UniProt P05106
Research Area Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications
Application Notes The suggested dilution is: WB: 1:500-1:1000
Comment

Background: The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.

Restrictions For Research Use only
Format Liquid
Concentration 1mg/ml
Buffer PBS, 0.02% sodium azide and 50% glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Addad, Elalamy, Chakroun et al.: "Platelet glycoprotein IIIa (platelet antigen 1/platelet antigen 2) polymorphism and 1-year outcome in patients with stable coronary artery disease." in: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, Vol. 21, Issue 7, pp. 674-8, 2010 (PubMed).

Motovska, Kvasnicka, Hajkova et al.: "Platelet gene polymorphisms and risk of bleeding in patients undergoing elective coronary angiography: a genetic substudy of the PRAGUE-8 trial." in: Atherosclerosis, Vol. 212, Issue 2, pp. 548-52, 2010 (PubMed).

Romero, Friel, Velez Edwards et al.: "A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)." in: American journal of obstetrics and gynecology, Vol. 203, Issue 4, pp. 361.e1-361.e30, 2010 (PubMed).

Nie, Zhou, Fu et al.: "The allele frequencies of HPA 1-16 determined by PCR-SSP in Chinese Cantonese donors." in: Transfusion medicine (Oxford, England), Vol. 20, Issue 6, pp. 376-82, 2010 (PubMed).

Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).

Validation Images
Catalog No. ABIN658966
464.29 $
Plus shipping costs $45.00
Quantity
Price
0.1 mg
464.29 $

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